Hepatic Epithelioid Hemangioendothelioma Successfully Treated with Living Donor Liver Transplantation: A Case Report and Literature Review

Overview

Journal Clin Case Rep

Date 2020 Jan 31

PMID 31998498

Citations 6

Authors

Sotaro Fukuhara

Hiroyuki Tahara

Yoshito Hirata

Kosuke Ono

Michinori Hamaoka

Seiichi Shimizu

Shinji Hashimoto

Shintaro Kuroda

Masahiro Ohira

Kentaro Ide

Tsuyoshi Kobayashi

Hideki Ohdan

Affiliations

Soon will be listed here.

Abstract

Hepatic epithelioid hemangioendothelioma is a rare neoplasm with a variable malignant potential and a high risk of recurrence. No general treatment guidelines have been established. Fortunately, we were able to minimize immunosuppressant after liver transplantation because of a full HLA-matched case. There was no recurrence 1 year after treatment.

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References

Rude M, Watson R, Crippin J . Recurrent hepatic epithelioid hemangioendothelioma after orthotopic liver transplantation. Hepatology. 2013; 59(5):2050-2. PMC: 4152982. DOI: 10.1002/hep.26891. View

Lai Q, Feys E, Karam V, Adam R, Klempnauer J, Oliverius M . Hepatic Epithelioid Hemangioendothelioma and Adult Liver Transplantation: Proposal for a Prognostic Score Based on the Analysis of the ELTR-ELITA Registry. Transplantation. 2017; 101(3):555-564. DOI: 10.1097/TP.0000000000001603. View

Grenader T, Vernea F, Reinus C, Gabizon A . Malignant epithelioid hemangioendothelioma of the liver successfully treated with pegylated liposomal doxorubicin. J Clin Oncol. 2011; 29(25):e722-4. DOI: 10.1200/JCO.2011.35.5891. View

Van de Stadt J, Gelin M, Adler M, LAMBILLIOTTE J . Epithelioid hemangioendothelioma and liver transplantation. Gastroenterology. 1989; 96(1):275-6. DOI: 10.1016/0016-5085(89)90823-8. View

Kayler L, Merion R, Arenas J, Magee J, Campbell D, Rudich S . Epithelioid hemangioendothelioma of the liver disseminated to the peritoneum treated with liver transplantation and interferon alpha-2B. Transplantation. 2002; 74(1):128-30. DOI: 10.1097/00007890-200207150-00022. View

Hasegawa K, Sugawara Y, Ikeda M, Ishizawa T, Ohashi K, Makuuchi M . Living donor liver transplantation for epithelioid hemangioendothelioma: Report of a case. Surg Today. 2006; 36(11):1024-7. DOI: 10.1007/s00595-006-3292-8. View

St Peter S, Moss A, Huettl E, Leslie K, Mulligan D . Chemoembolization followed by orthotopic liver transplant for epithelioid hemangioendothelioma. Clin Transplant. 2004; 17(6):549-53. DOI: 10.1046/j.1399-0012.2003.00055.x. View

Demetris A, Minervini M, Raikow R, Lee R . Hepatic epithelioid hemangioendothelioma: biological questions based on pattern of recurrence in an allograft and tumor immunophenotype. Am J Surg Pathol. 1997; 21(3):263-70. DOI: 10.1097/00000478-199703000-00001. View

Stacchiotti S, Provenzano S, Dagrada G, Negri T, Brich S, Basso U . Sirolimus in Advanced Epithelioid Hemangioendothelioma: A Retrospective Case-Series Analysis from the Italian Rare Cancer Network Database. Ann Surg Oncol. 2016; 23(9):2735-44. DOI: 10.1245/s10434-016-5331-z. View

10.

Fukuhara S, Tahara H, Hirata Y, Ono K, Hamaoka M, Shimizu S . Hepatic epithelioid hemangioendothelioma successfully treated with living donor liver transplantation: A case report and literature review. Clin Case Rep. 2020; 8(1):108-115. PMC: 6982499. DOI: 10.1002/ccr3.2558. View

11.

Sangro B, Inarrairaegui M, Fernandez-Ros N . Malignant epithelioid hemangioendothelioma of the liver successfully treated with Sorafenib. Rare Tumors. 2012; 4(2):e34. PMC: 3401162. DOI: 10.4081/rt.2012.e34. View

12.

Simpson N, Ahmed A, Simpson P, Parkar J, Keeffe E, Ahmed A . Living donor liver transplantation in a patient with hepatic epithelioid hemangioendothelioma. J Clin Gastroenterol. 2003; 37(4):349-50. DOI: 10.1097/00004836-200310000-00017. View

13.

Terg R, Bruguera M, Campo E, Hojman R, Levi D, Podesta A . Epithelioid hemangioendothelioma of the liver: report of two cases. Liver. 1988; 8(2):105-10. DOI: 10.1111/j.1600-0676.1988.tb00976.x. View

14.

Toso C, Merani S, Bigam D, Shapiro A, Kneteman N . Sirolimus-based immunosuppression is associated with increased survival after liver transplantation for hepatocellular carcinoma. Hepatology. 2010; 51(4):1237-43. DOI: 10.1002/hep.23437. View

15.

Lakkis Z, Kim S, Delabrousse E, Jary M, Nguyen T, Mantion G . Metronomic cyclophosphamide: an alternative treatment for hepatic epithelioid hemangioendothelioma. J Hepatol. 2013; 58(6):1254-7. DOI: 10.1016/j.jhep.2013.01.043. View

16.

Hertl M, Cosimi A . Liver transplantation for malignancy. Oncologist. 2005; 10(4):269-81. DOI: 10.1634/theoncologist.10-4-269. View

17.

Weiss S, ENZINGER F . Epithelioid hemangioendothelioma: a vascular tumor often mistaken for a carcinoma. Cancer. 1982; 50(5):970-81. DOI: 10.1002/1097-0142(19820901)50:5<970::aid-cncr2820500527>3.0.co;2-z. View

18.

Tan Y, Yang X, Dong C, Xiao Z, Zhang H, Wang Y . Diffuse hepatic epithelioid hemangioendothelioma with multiple splenic metastasis and delayed multifocal bone metastasis after liver transplantation on FDG PET/CT images: A case report. Medicine (Baltimore). 2018; 97(22):e10728. PMC: 6392553. DOI: 10.1097/MD.0000000000010728. View

19.

Dean P, Haggitt R, OHara C . Malignant epithelioid hemangioendothelioma of the liver in young women. Relationship to oral contraceptive use. Am J Surg Pathol. 1985; 9(10):695-704. DOI: 10.1097/00000478-198510000-00001. View

20.

Marino I, Todo S, Tzakis A, Klintmalm G, Kelleher M, Iwatsuki S . Treatment of hepatic epithelioid hemangioendothelioma with liver transplantation. Cancer. 1988; 62(10):2079-84. PMC: 2990224. DOI: 10.1002/1097-0142(19881115)62:10<2079::aid-cncr2820621002>3.0.co;2-j. View