Effects of Hemodialysis on Blood Fatty Acids

Overview

Journal Physiol Rep

Specialty Physiology

Date 2020 Jan 26

PMID 31981323

Citations 6

Authors

Benjamin Gollasch

Inci Dogan

Michael Rothe

Maik Gollasch

Friedrich C Luft

Affiliations

Soon will be listed here.

Abstract

Omega-3 (n-3) fatty acids have beneficial cardiovascular effects, perhaps also in chronic kidney disease (CKD) patients. A low omega-3 index is an independent cardiovascular risk factor in end-stage renal disease (ESRD) dialysis patients. However, the plasma measurements invariably ignore circulating blood cells, including the preponderant erythrocytes (RBCs). We measured fatty acids (HPLC-MS lipidomics) in all components of the circulating blood, since RBC n-3 fatty acid status has been linked to cardiovascular disease and mortality. We studied 15 healthy persons and 15 CKD patients undergoing regular hemodialysis treatments. While total fatty acid levels differed significantly in RBCs from healthy controls and CKD patients, the hemodialysis treatment had no effect on plasma or RBC fatty acid levels. No changes occurred in the percentage of eicosapentaenoic acid (C20:5 n-3, EPA) and docosahexaenoic acid (C22:6 n-3; DHA) (omega-3 quotient) in RBC membrane fatty acids. Nonetheless, hemodialysis treatments increased plasma levels of various total fatty acids, namely C12:0, C14:0, C16:0, C20:2 n-6, C20:4 n-6, and C22:6 n-3 (DHA), while plasma levels of free fatty acids were unchanged. These data suggest that despite significant changes in fatty acids signatures between healthy persons and CKD patients, hemodialysis does not alter RBC n-3 fatty acid status, including the omega-3 quotient. The dialysis treatment per se does not appear to be responsible for a lower omega-3 index in CKD patients.

Citing Articles

Bioaccumulation of Blood Long-Chain Fatty Acids during Hemodialysis.

Liu T, Dogan I, Rothe M, Reichardt J, Knauf F, Gollasch M Metabolites. 2022; 12(3).

PMID: 35323712 PMC: 8949028. DOI: 10.3390/metabo12030269.

Heart Rate Variability and Long Chain -3 Polyunsaturated Fatty Acids in Chronic Kidney Disease Patients on Haemodialysis: A Cross-Sectional Pilot Study.

Pinto A, MacLaughlin H, Hall W Nutrients. 2021; 13(7).

PMID: 34371962 PMC: 8308541. DOI: 10.3390/nu13072453.

Multi-Solvent Extraction Procedure for the Pioneer Fecal Metabolomic Analysis-Identification of Potential Biomarkers in Stable Kidney Transplant Patients.

Kouidhi S, Souai N, Alhujaily M, Zidi O, Kochbati A, Redissi A Diagnostics (Basel). 2021; 11(6).

PMID: 34073647 PMC: 8229050. DOI: 10.3390/diagnostics11060962.

Hemodialysis and erythrocyte epoxy fatty acids.

Gollasch B, Wu G, Liu T, Dogan I, Rothe M, Gollasch M Physiol Rep. 2020; 8(20):e14601.

PMID: 33112511 PMC: 7592498. DOI: 10.14814/phy2.14601.

Effects of hemodialysis on plasma oxylipins.

Gollasch B, Wu G, Dogan I, Rothe M, Gollasch M, Luft F Physiol Rep. 2020; 8(12):e14447.

PMID: 32562348 PMC: 7305238. DOI: 10.14814/phy2.14447.

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