Objective Comparison Between Platelet Rich Plasma Alone and in Combination with Physical Therapy in Dogs with Osteoarthritis Caused by Hip Dysplasia

Overview

Journal Animals (Basel)

Date 2020 Jan 25

PMID 31972961

Citations 12

Authors

Belen Cuervo

Monica Rubio

Deborah Chicharro

Elena Damia

Angelo Santana

Jose Maria Carrillo

Ayla Del Romero

Jose Manuel Vilar

Jose Joaquin Ceron

Joaquin Jesus Sopena

Affiliations

Soon will be listed here.

Abstract

Osteoarthritis (OA) is one of the most significant joint diseases worldwide. There are different therapies for OA treatment, and a relatively new strategy is the use of plasma rich in growth factors (PRGF), a platelet rich plasma (PRP) derivative. The objective of this study was to objectively assess the efficacy and duration of the effect of an intraarticular injection of PRGF and a combination of PRGF + physical therapy. The objective assessment was provided using a force platform. The obtained parameters were peak vertical force (PVF) and vertical impulse (VI). A total of 24 dogs with lameness and pain associated to OA attributable to bilateral hip dysplasia were included in the study. Animals were divided into two study groups and evaluated at baseline and at 30, 90, and 180 days after intraarticular PRGF or PRGF + physical therapy. Significant differences were observed at every checkpoint with respect to basal time in both groups. However, after 180 days, the PRGF group showed a decrease in PVF and VI with respect to the values obtained at 90 days. However, the PRGF + physical therapy group maintained increased values of both PVF and VI values during the 180-day study period.

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References

Slemenda C, Heilman D, Brandt K, Katz B, Mazzuca S, Braunstein E . Reduced quadriceps strength relative to body weight: a risk factor for knee osteoarthritis in women?. Arthritis Rheum. 1998; 41(11):1951-9. DOI: 10.1002/1529-0131(199811)41:11<1951::AID-ART9>3.0.CO;2-9. View

Rodriguez-Merchan E . Intraarticular Injections of Platelet-rich Plasma (PRP) in the Management of Knee Osteoarthritis. Arch Bone Jt Surg. 2014; 1(1):5-8. PMC: 4151401. View

Okuda K, Kawase T, Momose M, Murata M, Saito Y, Suzuki H . Platelet-rich plasma contains high levels of platelet-derived growth factor and transforming growth factor-beta and modulates the proliferation of periodontally related cells in vitro. J Periodontol. 2003; 74(6):849-57. DOI: 10.1902/jop.2003.74.6.849. View

Marx R . Platelet-rich plasma (PRP): what is PRP and what is not PRP?. Implant Dent. 2002; 10(4):225-8. DOI: 10.1097/00008505-200110000-00002. View

Wang-Saegusa A, Cugat R, Ares O, Seijas R, Cusco X, Garcia-Balletbo M . Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life. Arch Orthop Trauma Surg. 2010; 131(3):311-7. DOI: 10.1007/s00402-010-1167-3. View

Shah K, Drury T, Roic I, Hansen P, Malin M, Boyd R . Outcome of Allogeneic Adult Stem Cell Therapy in Dogs Suffering from Osteoarthritis and Other Joint Defects. Stem Cells Int. 2018; 2018:7309201. PMC: 6046133. DOI: 10.1155/2018/7309201. View

Eskelinen E, Liska W, Hyytiainen H, Hielm-Bjorkman A . Canine total knee replacement performed due to osteoarthritis subsequent to distal femur fracture osteosynthesis: two-year objective outcome. Vet Comp Orthop Traumatol. 2012; 25(5):427-32. DOI: 10.3415/VCOT-11-01-0012. View

Civinini R, Nistri L, Martini C, Redl B, Ristori G, Innocenti M . Growth factors in the treatment of early osteoarthritis. Clin Cases Miner Bone Metab. 2013; 10(1):26-9. PMC: 3710006. DOI: 10.11138/ccmbm/2013.10.1.026. View

Hunter D, Felson D . Osteoarthritis. BMJ. 2006; 332(7542):639-42. PMC: 1403209. DOI: 10.1136/bmj.332.7542.639. View

10.

Lopez S, Vilar J, Rubio M, Sopena J, Santana A, Rodriguez O . Pedobarography: a novel approach to test the efficacy of treatments for lameness; an experience with mavacoxib in dogs with elbow osteoarthritis. BMC Vet Res. 2019; 15(1):193. PMC: 6560748. DOI: 10.1186/s12917-019-1946-1. View

11.

Vilar J, Manera M, Santana A, Spinella G, Rodriguez O, Rubio M . Effect of leukocyte-reduced platelet-rich plasma on osteoarthritis caused by cranial cruciate ligament rupture: A canine gait analysis model. PLoS One. 2018; 13(3):e0194752. PMC: 5858837. DOI: 10.1371/journal.pone.0194752. View

12.

Anitua E . Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants. 1999; 14(4):529-35. View

13.

Rychel J . Diagnosis and treatment of osteoarthritis. Top Companion Anim Med. 2010; 25(1):20-5. DOI: 10.1053/j.tcam.2009.10.005. View

14.

Wu C, Chen W, Zao B, Lai P, Lin T, Lo H . Regenerative potentials of platelet-rich plasma enhanced by collagen in retrieving pro-inflammatory cytokine-inhibited chondrogenesis. Biomaterials. 2011; 32(25):5847-54. DOI: 10.1016/j.biomaterials.2011.05.002. View

15.

Kazemi D, Fakhrjou A, Dizaji V, Khanzadeh Alishahi M . Effect of autologous platelet rich fibrin on the healing of experimental articular cartilage defects of the knee in an animal model. Biomed Res Int. 2014; 2014:486436. PMC: 4083211. DOI: 10.1155/2014/486436. View

16.

Hunter D . Osteoarthritis. Rheum Dis Clin North Am. 2013; 39(1):xv-xviii. DOI: 10.1016/j.rdc.2012.11.005. View

17.

Cuervo B, Rubio M, Sopena J, Dominguez J, Vilar J, Morales M . Hip osteoarthritis in dogs: a randomized study using mesenchymal stem cells from adipose tissue and plasma rich in growth factors. Int J Mol Sci. 2014; 15(8):13437-60. PMC: 4159804. DOI: 10.3390/ijms150813437. View

18.

Malek S, Sample S, Schwartz Z, Nemke B, Jacobson P, Cozzi E . Effect of analgesic therapy on clinical outcome measures in a randomized controlled trial using client-owned dogs with hip osteoarthritis. BMC Vet Res. 2012; 8:185. PMC: 3527270. DOI: 10.1186/1746-6148-8-185. View

19.

Forogh B, Mianehsaz E, Shoaee S, Ahadi T, Raissi G, Sajadi S . Effect of single injection of platelet-rich plasma in comparison with corticosteroid on knee osteoarthritis: a double-blind randomized clinical trial. J Sports Med Phys Fitness. 2015; 56(7-8):901-8. View

20.

Anitua E, Andia I, Sanchez M, Azofra J, del Mar Zalduendo M, Fuente M . Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture. J Orthop Res. 2005; 23(2):281-6. DOI: 10.1016/j.orthres.2004.08.015. View