The Use of Platelet Rich Plasma in the Treatment of Degenerative Joint Disease in Cats: an Exploratory Case Series

Overview

Journal Front Vet Sci

Specialty Veterinary Medicine

Date 2024 Jun 12

PMID 38863451

Authors

Janice Huntingford

Andrea Looney

James Johnson

Lisa Miller

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the effectiveness of intra-articular autologous Platelet Rich Plasma (PRP) in managing Degenerative Joint Disease (DJD) in cats.

Design: Prospective pilot clinical trial.

Methods: Six domestic cats with clinically and radiographically diagnosed DJD received intra-articular injections of autologous PRP. Clinical assessments pre and post intra-articular injections were conducted using the Feline Musculoskeletal Pain Index (FMPI, owner assessed) and Visual Analog Scale (VAS, clinician assessed) at baseline, Day 14, Day 28, and Day 42-45.

Results: Significant improvements were noted in both FMPI and VAS scores at the end of the study period, indicating enhanced joint function and reduced pain.

Conclusion And Clinical Relevance: The study suggests the potential of PRP therapy as a safe and effective treatment for feline DJD, warranting further research with larger cohorts and longer follow-up to establish comprehensive treatment guidelines.

References

Cuenca-Zamora E, Ferrer-Marin F, Rivera J, Teruel-Montoya R . Tubulin in Platelets: When the Shape Matters. Int J Mol Sci. 2019; 20(14). PMC: 6678703. DOI: 10.3390/ijms20143484. View

Lascelles B, Henry 3rd J, Brown J, Robertson I, Sumrell A, Simpson W . Cross-sectional study of the prevalence of radiographic degenerative joint disease in domesticated cats. Vet Surg. 2010; 39(5):535-44. DOI: 10.1111/j.1532-950X.2010.00708.x. View

Alves J, Santos A, Jorge P . Platelet-rich plasma therapy in dogs with bilateral hip osteoarthritis. BMC Vet Res. 2021; 17(1):207. PMC: 8180029. DOI: 10.1186/s12917-021-02913-x. View

Yun S, Ku S, Kwon Y . Adipose-derived mesenchymal stem cells and platelet-rich plasma synergistically ameliorate the surgical-induced osteoarthritis in Beagle dogs. J Orthop Surg Res. 2016; 11:9. PMC: 4714505. DOI: 10.1186/s13018-016-0342-9. View

Deal J, Smith E, Heard W, OBrien M, Savoie 3rd F . Platelet-Rich Plasma for Primary Treatment of Partial Ulnar Collateral Ligament Tears: MRI Correlation With Results. Orthop J Sports Med. 2017; 5(11):2325967117738238. PMC: 5686880. DOI: 10.1177/2325967117738238. View

Fang J, Wang X, Jiang W, Zhu Y, Hu Y, Zhao Y . Platelet-Rich Plasma Therapy in the Treatment of Diseases Associated with Orthopedic Injuries. Tissue Eng Part B Rev. 2020; 26(6):571-585. PMC: 9208862. DOI: 10.1089/ten.TEB.2019.0292. View

Anitua E, Andia I, Ardanza B, Nurden P, Nurden A . Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost. 2003; 91(1):4-15. DOI: 10.1160/TH03-07-0440. View

Dhurat R, Sukesh M . Principles and Methods of Preparation of Platelet-Rich Plasma: A Review and Author's Perspective. J Cutan Aesthet Surg. 2015; 7(4):189-97. PMC: 4338460. DOI: 10.4103/0974-2077.150734. View

Hardie E, Roe S, Martin F . Radiographic evidence of degenerative joint disease in geriatric cats: 100 cases (1994-1997). J Am Vet Med Assoc. 2002; 220(5):628-32. DOI: 10.2460/javma.2002.220.628. View

10.

Hsu W, Mishra A, Rodeo S, Fu F, Terry M, Randelli P . Platelet-rich plasma in orthopaedic applications: evidence-based recommendations for treatment. J Am Acad Orthop Surg. 2013; 21(12):739-48. DOI: 10.5435/JAAOS-21-12-739. View

11.

Marx R . Platelet-rich plasma (PRP): what is PRP and what is not PRP?. Implant Dent. 2002; 10(4):225-8. DOI: 10.1097/00008505-200110000-00002. View

12.

Ferrari J, Schwartz P . Prospective Evaluation of Feline Sourced Platelet-Rich Plasma Using Centrifuge-Based Systems. Front Vet Sci. 2020; 7:322. PMC: 7303265. DOI: 10.3389/fvets.2020.00322. View

13.

Cuervo B, Rubio M, Chicharro D, Damia E, Santana A, Carrillo J . Objective Comparison between Platelet Rich Plasma Alone and in Combination with Physical Therapy in Dogs with Osteoarthritis Caused by Hip Dysplasia. Animals (Basel). 2020; 10(2). PMC: 7070503. DOI: 10.3390/ani10020175. View

14.

Carr B, Canapp Jr S, Mason D, Cox C, Hess T . Canine Platelet-Rich Plasma Systems: A Prospective Analysis. Front Vet Sci. 2016; 2:73. PMC: 4700921. DOI: 10.3389/fvets.2015.00073. View

15.

Saito M, Takahashi K, Arai Y, Inoue A, Sakao K, Tonomura H . Intraarticular administration of platelet-rich plasma with biodegradable gelatin hydrogel microspheres prevents osteoarthritis progression in the rabbit knee. Clin Exp Rheumatol. 2009; 27(2):201-7. View

16.

Smith M, Smith W . Emerging techniques in orthopaedics: platelet-rich plasma. Orthop Nurs. 2011; 30(4):260-3. DOI: 10.1097/NOR.0b013e3182247c42. View

17.

Manole C, Soare C, Ceafalan L, Voiculescu V . Platelet-Rich Plasma in Dermatology: New Insights on the Cellular Mechanism of Skin Repair and Regeneration. Life (Basel). 2024; 14(1). PMC: 10817627. DOI: 10.3390/life14010040. View

18.

Garbin L, Olver C . Platelet-Rich Products and Their Application to Osteoarthritis. J Equine Vet Sci. 2020; 86:102820. DOI: 10.1016/j.jevs.2019.102820. View

19.

Lascelles B, Hansen B, Roe S, DePuy V, Thomson A, Pierce C . Evaluation of client-specific outcome measures and activity monitoring to measure pain relief in cats with osteoarthritis. J Vet Intern Med. 2007; 21(3):410-6. DOI: 10.1892/0891-6640(2007)21[410:eocoma]2.0.co;2. View

20.

Yang J, Yang K, Lee K, Choi S, Kim B, Park J . Effects of platelet-rich plasma on tooth replantation in dogs: a histologic and histomorphometric analysis. J Periodontal Implant Sci. 2018; 48(4):224-235. PMC: 6125669. DOI: 10.5051/jpis.2018.48.4.224. View