Intraarticular Injections of Platelet-rich Plasma (PRP) in the Management of Knee Osteoarthritis

Overview

Journal Arch Bone Jt Surg

Date 2014 Sep 11

PMID 25207275

Citations 12

Authors

E Carlos Rodriguez-Merchan

Affiliations

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Abstract

The clinical use of PRP therapy in the practical setting of orthopaedic fields is increasing partly because of the accessibility of devices that are used in outpatient preparation and delivery. Another reason is the strong advertisement of PRP procedures as the ultimate treatment and novel technology for knee problems by a few orthopaedic surgeons based on claims of abundant scientific evidence. Hence, PubMed articles related to the clinical use of PRP in knee osteoarthritis were searched using the key words: PRP, knee and osteoarthritis in order to study these claims. A total of 20 reports were found directly related to the topic. The aforementioned clinical studies suggest that intraarticular injections of PRP could have preventive effects against osteoarthritis progression. However, presently there is no clear evidence from well-designed clinical trials that intraarticular injections of PRP are efficacious in osteoarthritis. Therefore, at this time the efficacy of PRP requires more investigation, wherein better scientific studies should be performed that include high powered randomized controlled trials.

Citing Articles

Intra-Articular Platelet-Rich Plasma Injections in Knee Osteoarthritis: A Review of Their Current Molecular Mechanisms of Action and Their Degree of Efficacy.

Rodriguez-Merchan E Int J Mol Sci. 2022; 23(3).

PMID: 35163225 PMC: 8836227. DOI: 10.3390/ijms23031301.

Comparative Analysis of the Effectiveness of Intra-Articular Injection of Platelet-Rich Plasma versus Hyaluronic Acid for Knee Osteoarthritis: Results of an Open-Label Trial.

Jalali Jivan S, Monzavi S, Zargaran B, Alamdari D, Tavakol Afshari J, Etemad-Rezaie A Arch Bone Jt Surg. 2021; 9(5):487-495.

PMID: 34692930 PMC: 8503763. DOI: 10.22038/abjs.2021.52003.2569.

Chondroprotective Effects of Combination Therapy of Acupotomy and Human Adipose Mesenchymal Stem Cells in Knee Osteoarthritis Rabbits via the GSK3β-Cyclin D1-CDK4/CDK6 Signaling Pathway.

An X, Wang T, Zhang W, Yu H, Zhao R, Guo Y Aging Dis. 2020; 11(5):1116-1132.

PMID: 33014527 PMC: 7505269. DOI: 10.14336/AD.2019.1104.

Objective Comparison between Platelet Rich Plasma Alone and in Combination with Physical Therapy in Dogs with Osteoarthritis Caused by Hip Dysplasia.

Cuervo B, Rubio M, Chicharro D, Damia E, Santana A, Carrillo J Animals (Basel). 2020; 10(2).

PMID: 31972961 PMC: 7070503. DOI: 10.3390/ani10020175.

Combination treatment of captopril and prazosin to treat patients with gestational hypertension.

Hong B, Ding X, Iia H, Zhang J Exp Ther Med. 2018; 16(4):3694-3702.

PMID: 30233728 PMC: 6143910. DOI: 10.3892/etm.2018.6604.

References

Torrero J, Aroles F, Ferrer D . Treatment of knee chondropathy with platelet rich plasma. Preliminary results at 6 months of follow-up with only one injection. J Biol Regul Homeost Agents. 2013; 26(2 Suppl 1):71S-78S. View

Kon E, Buda R, Filardo G, Di Martino A, Timoncini A, Cenacchi A . Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions. Knee Surg Sports Traumatol Arthrosc. 2009; 18(4):472-9. DOI: 10.1007/s00167-009-0940-8. View

Sanchez M, Anitua E, Azofra J, Aguirre J, Andia I . Intra-articular injection of an autologous preparation rich in growth factors for the treatment of knee OA: a retrospective cohort study. Clin Exp Rheumatol. 2008; 26(5):910-3. View

Smelter E, Hochberg M . New treatments for osteoarthritis. Curr Opin Rheumatol. 2013; 25(3):310-6. DOI: 10.1097/BOR.0b013e32835f69b4. View

Park Y, Han S, Song S, Kim T, Ha C . Platelet-rich plasma therapy for knee joint problems: review of the literature, current practice and legal perspectives in Korea. Knee Surg Relat Res. 2012; 24(2):70-8. PMC: 3374002. DOI: 10.5792/ksrr.2012.24.2.70. View

Rodeo S, Delos D, Weber A, Ju X, Cunningham M, Fortier L . What's new in orthopaedic research. J Bone Joint Surg Am. 2010; 92(14):2491-501. DOI: 10.2106/JBJS.J.01174. View

Hart R, Safi A, Komzak M, Jajtner P, Puskeiler M, Hartova P . Platelet-rich plasma in patients with tibiofemoral cartilage degeneration. Arch Orthop Trauma Surg. 2013; 133(9):1295-301. DOI: 10.1007/s00402-013-1782-x. View

Gobbi A, Karnatzikos G, Mahajan V, Malchira S . Platelet-rich plasma treatment in symptomatic patients with knee osteoarthritis: preliminary results in a group of active patients. Sports Health. 2012; 4(2):162-72. PMC: 3435904. DOI: 10.1177/1941738111431801. View

Jang S, Kim J, Cha S . Platelet-rich plasma (PRP) injections as an effective treatment for early osteoarthritis. Eur J Orthop Surg Traumatol. 2013; 23(5):573-80. DOI: 10.1007/s00590-012-1037-5. View

10.

Patel S, Dhillon M, Aggarwal S, Marwaha N, Jain A . Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: a prospective, double-blind, randomized trial. Am J Sports Med. 2013; 41(2):356-64. DOI: 10.1177/0363546512471299. View

11.

Filardo G, Kon E, Buda R, Timoncini A, Di Martino A, Cenacchi A . Platelet-rich plasma intra-articular knee injections for the treatment of degenerative cartilage lesions and osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2010; 19(4):528-35. DOI: 10.1007/s00167-010-1238-6. View

12.

Dhillon M, Patel S, Bali K . Platelet-rich plasma intra-articular knee injections for the treatment of degenerative cartilage lesions and osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2010; 19(5):863-4. DOI: 10.1007/s00167-010-1339-2. View

13.

Sampson S, Reed M, Silvers H, Meng M, Mandelbaum B . Injection of platelet-rich plasma in patients with primary and secondary knee osteoarthritis: a pilot study. Am J Phys Med Rehabil. 2011; 89(12):961-9. DOI: 10.1097/PHM.0b013e3181fc7edf. View

14.

Cerza F, Carni S, Alessandro Carcangiu , Di Vavo I, Schiavilla V, Pecora A . Comparison between hyaluronic acid and platelet-rich plasma, intra-articular infiltration in the treatment of gonarthrosis. Am J Sports Med. 2012; 40(12):2822-7. DOI: 10.1177/0363546512461902. View

15.

Filardo G, Kon E, Di Martino A, Di Matteo B, Merli M, Cenacchi A . Platelet-rich plasma vs hyaluronic acid to treat knee degenerative pathology: study design and preliminary results of a randomized controlled trial. BMC Musculoskelet Disord. 2012; 13:229. PMC: 3532098. DOI: 10.1186/1471-2474-13-229. View

16.

Wang-Saegusa A, Cugat R, Ares O, Seijas R, Cusco X, Garcia-Balletbo M . Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life. Arch Orthop Trauma Surg. 2010; 131(3):311-7. DOI: 10.1007/s00402-010-1167-3. View

17.

Dhollander A, De Neve F, Almqvist K, Verdonk R, Lambrecht S, Elewaut D . Autologous matrix-induced chondrogenesis combined with platelet-rich plasma gel: technical description and a five pilot patients report. Knee Surg Sports Traumatol Arthrosc. 2010; 19(4):536-42. DOI: 10.1007/s00167-010-1337-4. View

18.

Koh Y, Choi Y . Infrapatellar fat pad-derived mesenchymal stem cell therapy for knee osteoarthritis. Knee. 2012; 19(6):902-7. DOI: 10.1016/j.knee.2012.04.001. View

19.

Filardo G, Kon E, Pereira Ruiz M, Vaccaro F, Guitaldi R, Di Martino A . Platelet-rich plasma intra-articular injections for cartilage degeneration and osteoarthritis: single- versus double-spinning approach. Knee Surg Sports Traumatol Arthrosc. 2011; 20(10):2082-91. DOI: 10.1007/s00167-011-1837-x. View

20.

Lubowitz J, Poehling G . Shoulder, hip, knee, and PRP. Arthroscopy. 2010; 26(2):141-2. DOI: 10.1016/j.arthro.2009.12.005. View