Innate Immune Cells, Major Protagonists of Sickle Cell Disease Pathophysiology

Overview

Journal Haematologica

Specialty Hematology

Date 2020 Jan 11

PMID 31919091

Citations 25

Authors

Slimane Allali

Thiago Trovati Maciel

Olivier Hermine

Mariane De Montalembert

Affiliations

Soon will be listed here.

Abstract

Sickle cell disease (SCD), considered the most common monogenic disease worldwide, is a severe hemoglobin disorder. Although the genetic and molecular bases have long been characterized, the pathophysiology remains incompletely elucidated and therapeutic options are limited. It has been increasingly suggested that innate immune cells, including monocytes, neutrophils, invariant natural killer T cells, platelets and mast cells, have a role in promoting inflammation, adhesion and pain in SCD. Here we provide a thorough review of the involvement of these novel, major protagonists in SCD pathophysiology, highlighting recent evidence for innovative therapeutic perspectives.

Citing Articles

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