Red Blood Cell Alloimmunization in Sickle Cell Disease: Pathophysiology, Risk Factors, and Transfusion Management

Overview

Journal Blood

Publisher Elsevier

Specialty Hematology

Date 2012 May 8

PMID 22563085

Citations 143

Authors

Karina Yazdanbakhsh

Russell E Ware

France Noizat-Pirenne

Affiliations

Soon will be listed here.

Abstract

Red blood cell transfusions have reduced morbidity and mortality for patients with sickle cell disease. Transfusions can lead to erythrocyte alloimmunization, however, with serious complications for the patient including life-threatening delayed hemolytic transfusion reactions and difficulty in finding compatible units, which can cause transfusion delays. In this review, we discuss the risk factors associated with alloimmunization with emphasis on possible mechanisms that can trigger delayed hemolytic transfusion reactions in sickle cell disease, and we describe the challenges in transfusion management of these patients, including opportunities and emerging approaches for minimizing this life-threatening complication.

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