Templated Collagen "Double Helices" Maintain Their Structure

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2020 Jan 3

PMID 31895554

Citations 7

Authors

I Caglar Tanrikulu

William M Westler

Aubrey J Ellison

John L Markley

Ronald T Raines

Affiliations

Soon will be listed here.

Abstract

The self-assembly of collagen-mimetic peptides (CMPs) that form sticky-ended triple helices has allowed the production of surprisingly stable artificial collagen fibers and hydrogels. Assembly through sticky ends requires the recognition of a single strand by a templated strand dimer. Although CMPs and their triple helices have been studied extensively, the structure of a strand dimer is unknown. Here, we evaluate the physical characteristics of such dimers, using disulfide-templated (PPG) dimers as a model. Such "linked-dimers" retain their collagen-like structure even in the absence of a third strand, but only when their strands are capable of adopting a triple-helical fold. The intrinsic collagen-like structure of templated CMP pairs helps to explain the success of sticky-ended CMP association and changes the conception of new synthetic collagen designs.

Citing Articles

Heterotrimeric collagen helix with high specificity of assembly results in a rapid rate of folding.

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Synthetic Collagen Hydrogels through Symmetric Self-Assembly of Small Peptides.

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