Precision Medicine Approaches to Prevent Gastric Cancer

Overview

Journal Gut Liver

Specialty Gastroenterology

Date 2020 Jan 3

PMID 31893631

Citations 21

Authors

Juntaro Matsuzaki

Hitoshi Tsugawa

Hidekazu Suzuki

Affiliations

Soon will be listed here.

Abstract

Gastric cancer remains one of the most common causes of cancer-related death worldwide, although the incidence is declining gradually. The primary risk factor for gastric cancer is infection. The Kyoto global consensus report recommends eradication of in all infected patients. However, because it is difficult to stratify the risk of carcinogenesis among patients with a history of infection, annual endoscopic surveillance is performed for everyone after eradication. This review summarizes the current approaches used to screen for novel molecules that could assist in the diagnosis of gastric cancer and reduce mortality. Most well-studied molecules are tissue protein biomarkers expressed by the gastric epithelium and associated with metaplasia-dysplasia-carcinoma sequences. Other strategies focus on the origin of cancer stem cell-related markers, such as CD44, and immune reaction-related markers, such as matrix metallopeptidases. Noninvasive methods such as blood-based approaches are more attractive. Serum pepsinogen levels predict the severity of gastric mucosal atrophy before eradication, whereas plasma ghrelin levels are associated with atrophy even after eradication. Cell-free DNAs and RNAs are attractive tools for the early detection of cancer. These ideas could lead to the development of more personalized strategies for cancer prevention based on cutting-edge technologies.

Citing Articles

Immune Cell Crisis and Excess Histopathological Features During the Development and Progression of Infection in the Gastric Mucosa.

Wang S, Wang Y, Li P, Kong L, Deng W, Jiang B Int J Gen Med. 2025; 18:1345-1357.

PMID: 40065979 PMC: 11892368. DOI: 10.2147/IJGM.S474925.

Immune cell changes in infection-induced glandular epithelial cell damage of the gastric mucosa.

Wang S, Yun T, Zhu C, Li P, Ge D, Li S Ann Med. 2024; 56(1):2425072.

PMID: 39512155 PMC: 11552272. DOI: 10.1080/07853890.2024.2425072.

Protein Biomarkers of Gastric Preneoplasia and Cancer Lesions in Blood: A Comprehensive Review.

Bazin T, Nozeret K, Julie C, Lamarque D, Touati E Cancers (Basel). 2024; 16(17).

PMID: 39272877 PMC: 11394471. DOI: 10.3390/cancers16173019.

Diagnostic and prognostic value of CD44v9 and TIM3 expression in CK and CK regions in gastric cancer tissues.

Wang X, Lu L, Yang R, Wang Z, Li Q, Li J Oncol Lett. 2024; 28(4):479.

PMID: 39161328 PMC: 11332578. DOI: 10.3892/ol.2024.14612.

Implications of lncRNAs in -associated gastrointestinal cancers: underlying mechanisms and future perspectives.

Zhang L, Yu F, Zhang Y, Li P Front Cell Infect Microbiol. 2024; 14:1392129.

PMID: 39035354 PMC: 11257847. DOI: 10.3389/fcimb.2024.1392129.

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