Current Insights into Oral Cancer Epigenetics

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2018 Mar 3

PMID 29495520

Citations 33

Authors

Alexandra Iulia Irimie

Cristina Ciocan

Diana Gulei

Nikolay Mehterov

Atanas G Atanasov

Diana Dudea

Ioana Berindan-Neagoe

Affiliations

Soon will be listed here.

Abstract

Epigenetic modifications have emerged into one of the cancer hallmarks, replacing the concept of malignant pathologies as being solely genetic-based conditions. The epigenetic landscape is responsible for normal development but also for the heterogeneity among tissues in terms of gene expression patterns. Dysregulation in these mechanisms has been associated with disease stage, and increased attention is now granted to cancer in order to take advantage of these modifications in terms of novel therapeutic strategies or diagnosis/prognosis tools. Oral cancer has also been subjected to epigenetic analysis with numerous studies revealing that the development and progression of this malignancy are partially induced by an altered epigenetic substrate together with genetic alterations and prolonged exposure to environmental risk factors. The present review summarizes the most important epigenetic modifications associated with oral cancer and also their potential to be used as new therapeutic targets.

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References

Ley T, Ding L, Walter M, McLellan M, Lamprecht T, Larson D . DNMT3A mutations in acute myeloid leukemia. N Engl J Med. 2010; 363(25):2424-33. PMC: 3201818. DOI: 10.1056/NEJMoa1005143. View

Aoki K, Taketo M . Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene. J Cell Sci. 2007; 120(Pt 19):3327-35. DOI: 10.1242/jcs.03485. View

Shin K, Kim J, Rho K, Park K, Oh J, Min B . Inactivation of the PTEN gene by mutation, exonic deletion, and loss of transcript in human oral squamous cell carcinomas. Int J Oncol. 2002; 21(5):997-1001. View

Staibano S, Mascolo M, Rocco A, Lo Muzio L, Ilardi G, Siano M . The proliferation marker Chromatin Assembly Factor-1 is of clinical value in predicting the biological behaviour of salivary gland tumours. Oncol Rep. 2010; 25(1):13-22. View

Heyn H, Esteller M . DNA methylation profiling in the clinic: applications and challenges. Nat Rev Genet. 2012; 13(10):679-92. DOI: 10.1038/nrg3270. View

Shivaswamy S, Bhinge A, Zhao Y, Jones S, Hirst M, Iyer V . Dynamic remodeling of individual nucleosomes across a eukaryotic genome in response to transcriptional perturbation. PLoS Biol. 2008; 6(3):e65. PMC: 2267817. DOI: 10.1371/journal.pbio.0060065. View

Yoo C, Jones P . Epigenetic therapy of cancer: past, present and future. Nat Rev Drug Discov. 2006; 5(1):37-50. DOI: 10.1038/nrd1930. View

Yuan G, Liu Y, Dion M, Slack M, Wu L, Altschuler S . Genome-scale identification of nucleosome positions in S. cerevisiae. Science. 2005; 309(5734):626-30. DOI: 10.1126/science.1112178. View

Gasche J, Goel A . Epigenetic mechanisms in oral carcinogenesis. Future Oncol. 2012; 8(11):1407-25. PMC: 3569850. DOI: 10.2217/fon.12.138. View

10.

Sato T, Suzuki M, Sato Y, Echigo S, Rikiishi H . Sequence-dependent interaction between cisplatin and histone deacetylase inhibitors in human oral squamous cell carcinoma cells. Int J Oncol. 2006; 28(5):1233-41. View

11.

Eckhardt F, Lewin J, Cortese R, Rakyan V, Attwood J, Burger M . DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet. 2006; 38(12):1378-85. PMC: 3082778. DOI: 10.1038/ng1909. View

12.

Robertson K . DNA methylation and human disease. Nat Rev Genet. 2005; 6(8):597-610. DOI: 10.1038/nrg1655. View

13.

Jithesh P, Risk J, Schache A, Dhanda J, Lane B, Liloglou T . The epigenetic landscape of oral squamous cell carcinoma. Br J Cancer. 2013; 108(2):370-9. PMC: 3566828. DOI: 10.1038/bjc.2012.568. View

14.

Youssef E, Lotan D, Issa J, Wakasa K, Fan Y, Mao L . Hypermethylation of the retinoic acid receptor-beta(2) gene in head and neck carcinogenesis. Clin Cancer Res. 2004; 10(5):1733-42. DOI: 10.1158/1078-0432.ccr-0989-3. View

15.

Kato K, Long N, Makita H, Toida M, Yamashita T, Hatakeyama D . Effects of green tea polyphenol on methylation status of RECK gene and cancer cell invasion in oral squamous cell carcinoma cells. Br J Cancer. 2008; 99(4):647-54. PMC: 2527823. DOI: 10.1038/sj.bjc.6604521. View

16.

Kurasawa Y, Shiiba M, Nakamura M, Fushimi K, Ishigami T, Bukawa H . PTEN expression and methylation status in oral squamous cell carcinoma. Oncol Rep. 2008; 19(6):1429-34. View

17.

Huang M, Yeh K, Shih H, Wang Y, Lin T, Chang J . The correlation between CpG methylation and protein expression of P16 in oral squamous cell carcinomas. Int J Mol Med. 2002; 10(5):551-4. View

18.

Irimie A, Braicu C, Pileczki V, Petrushev B, Soritau O, Campian R . Knocking down of p53 triggers apoptosis and autophagy, concomitantly with inhibition of migration on SSC-4 oral squamous carcinoma cells. Mol Cell Biochem. 2016; 419(1-2):75-82. DOI: 10.1007/s11010-016-2751-9. View

19.

Czerninski R, Krichevsky S, Ashhab Y, Gazit D, Patel V, Ben-Yehuda D . Promoter hypermethylation of mismatch repair genes, hMLH1 and hMSH2 in oral squamous cell carcinoma. Oral Dis. 2009; 15(3):206-13. DOI: 10.1111/j.1601-0825.2008.01510.x. View

20.

Sanchez-Cespedes M, Esteller M, Wu L, Yoo G, Koch W, Jen J . Gene promoter hypermethylation in tumors and serum of head and neck cancer patients. Cancer Res. 2000; 60(4):892-5. View