Lateral Flow Biosensors Based on the Use of Micro- and Nanomaterials: a Review on Recent Developments

Overview

Journal Mikrochim Acta

Specialties Biotechnology
Chemistry

Date 2019 Dec 20

PMID 31853644

Citations 37

Authors

Yan Huang

Tailin Xu

Wenqian Wang

Yongqiang Wen

Kun Li

Lisheng Qian

Xueji Zhang

Guodong Liu

Affiliations

Soon will be listed here.

Abstract

This review (with 187 refs.) summarizes the progress that has been made in the design of lateral flow biosensors (LFBs) based on the use of micro- and nano-materials. Following a short introduction into the field, a first section covers features related to the design of LFBs, with subsections on strip-based, cotton thread-based and vertical flow- and syringe-based LFBs. The next chapter summarizes methods for sample pretreatment, from simple method to membrane-based methods, pretreatment by magnetic methods to device-integrated sample preparation. Advances in flow control are treated next, with subsections on cross-flow strategies, delayed and controlled release and various other strategies. Detection conditionst and mathematical modelling are briefly introduced in the following chapter. A further chapter covers methods for reliability improvement, for example by adding other validation lines or adopting different detection methods. Signal readouts are summarized next, with subsections on color-based, luminescent, smartphone-based and SERS-based methods. A concluding section summarizes the current status and addresses challenges in future perspectives. Graphical abstractRecent development and breakthrough points of lateral flow biosensors.

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References

Kim T, Park J, Kim C, Cho Y . Fully integrated lab-on-a-disc for nucleic acid analysis of food-borne pathogens. Anal Chem. 2014; 86(8):3841-8. DOI: 10.1021/ac403971h. View

Wang D, Tian B, Zhang Z, Wang X, Fleming J, Bi L . Detection of Bacillus anthracis spores by super-paramagnetic lateral-flow immunoassays based on "Road Closure". Biosens Bioelectron. 2014; 67:608-14. DOI: 10.1016/j.bios.2014.09.067. View

John A, Price C . Existing and Emerging Technologies for Point-of-Care Testing. Clin Biochem Rev. 2014; 35(3):155-67. PMC: 4204237. View

Mao X, Du T, Meng L, Song T . Novel gold nanoparticle trimer reporter probe combined with dry-reagent cotton thread immunoassay device for rapid human ferritin test. Anal Chim Acta. 2015; 889:172-8. DOI: 10.1016/j.aca.2015.06.031. View

Choi J, Liu Z, Hu J, Tang R, Gong Y, Feng S . Polydimethylsiloxane-Paper Hybrid Lateral Flow Assay for Highly Sensitive Point-of-Care Nucleic Acid Testing. Anal Chem. 2016; 88(12):6254-64. DOI: 10.1021/acs.analchem.6b00195. View

Fridley G, LE H, Yager P . Highly sensitive immunoassay based on controlled rehydration of patterned reagents in a 2-dimensional paper network. Anal Chem. 2014; 86(13):6447-53. PMC: 4082385. DOI: 10.1021/ac500872j. View

Zhu X, Shah P, Stoff S, Liu H, Li C . A paper electrode integrated lateral flow immunosensor for quantitative analysis of oxidative stress induced DNA damage. Analyst. 2014; 139(11):2850-7. PMC: 4074529. DOI: 10.1039/c4an00313f. View

Fu X, Cheng Z, Yu J, Choo P, Chen L, Choo J . A SERS-based lateral flow assay biosensor for highly sensitive detection of HIV-1 DNA. Biosens Bioelectron. 2015; 78:530-537. DOI: 10.1016/j.bios.2015.11.099. View

Yew C, Azari P, Choi J, Li F, Pingguan-Murphy B . Electrospin-coating of nitrocellulose membrane enhances sensitivity in nucleic acid-based lateral flow assay. Anal Chim Acta. 2018; 1009:81-88. DOI: 10.1016/j.aca.2018.01.016. View

10.

Wu F, Yuan H, Zhou C, Mao M, Liu Q, Shen H . Multiplexed detection of influenza A virus subtype H5 and H9 via quantum dot-based immunoassay. Biosens Bioelectron. 2015; 77:464-70. PMC: 7126372. DOI: 10.1016/j.bios.2015.10.002. View

11.

Zhang J, Lv X, Feng W, Li X, Li K, Deng Y . Aptamer-based fluorometric lateral flow assay for creatine kinase MB. Mikrochim Acta. 2018; 185(8):364. DOI: 10.1007/s00604-018-2905-4. View

12.

Wang R, Zhang W, Wang P, Su X . A paper-based competitive lateral flow immunoassay for multi β-agonist residues by using a single monoclonal antibody labelled with red fluorescent nanoparticles. Mikrochim Acta. 2018; 185(3):191. PMC: 5823949. DOI: 10.1007/s00604-018-2730-9. View

13.

Blazkova M, Rauch P, Fukal L . Strip-based immunoassay for rapid detection of thiabendazole. Biosens Bioelectron. 2010; 25(9):2122-8. DOI: 10.1016/j.bios.2010.02.011. View

14.

Fang Z, Wu W, Lu X, Zeng L . Lateral flow biosensor for DNA extraction-free detection of Salmonella based on aptamer mediated strand displacement amplification. Biosens Bioelectron. 2014; 56:192-7. DOI: 10.1016/j.bios.2014.01.015. View

15.

Ozalp V, Zeydanli U, Lunding A, Kavruk M, Oz M, Eyidogan F . Nanoparticle embedded enzymes for improved lateral flow sensors. Analyst. 2013; 138(15):4255-9. DOI: 10.1039/c3an00733b. View

16.

He Y, Zeng K, Gurung A, Baloda M, Xu H, Zhang X . Visual detection of single-nucleotide polymorphism with hairpin oligonucleotide-functionalized gold nanoparticles. Anal Chem. 2010; 82(17):7169-77. DOI: 10.1021/ac101275s. View

17.

You M, Lin M, Gong Y, Wang S, Li A, Ji L . Household Fluorescent Lateral Flow Strip Platform for Sensitive and Quantitative Prognosis of Heart Failure Using Dual-Color Upconversion Nanoparticles. ACS Nano. 2017; 11(6):6261-6270. DOI: 10.1021/acsnano.7b02466. View

18.

He Y, Zhang X, Zeng K, Zhang S, Baloda M, Gurung A . Visual detection of Hg²⁺ in aqueous solution using gold nanoparticles and thymine-rich hairpin DNA probes. Biosens Bioelectron. 2011; 26(11):4464-70. PMC: 3220944. DOI: 10.1016/j.bios.2011.05.003. View

19.

Kalogianni D, Boutsika L, Kouremenou P, Christopoulos T, Ioannou P . Carbon nano-strings as reporters in lateral flow devices for DNA sensing by hybridization. Anal Bioanal Chem. 2011; 400(4):1145-52. DOI: 10.1007/s00216-011-4845-2. View

20.

Cheng N, Song Y, Fu Q, Du D, Luo Y, Wang Y . Aptasensor based on fluorophore-quencher nano-pair and smartphone spectrum reader for on-site quantification of multi-pesticides. Biosens Bioelectron. 2018; 117:75-83. PMC: 8672368. DOI: 10.1016/j.bios.2018.06.002. View