Essential Functions of Runx/Cbfβ in Gut Conventional Dendritic Cells for Priming Rorγt T Cells

Overview

Journal Life Sci Alliance

Specialties Biochemistry
Biology
Cell Biology
Molecular Biology

Date 2019 Dec 11

PMID 31818882

Citations 5

Authors

Mari Tenno

Alicia Yoke Wei Wong

Mika Ikegaya

Eiji Miyauchi

Wooseok Seo

Peter See

Tamotsu Kato

Takashi Taida

Michiko Ohno-Oishi

Hiroshi Ohno

Hideyuki Yoshida

Florent Ginhoux

Ichiro Taniuchi

Affiliations

Soon will be listed here.

Abstract

Acquired immune responses are initiated by activation of CD4 helper T (Th) cells via recognition of antigens presented by conventional dendritic cells (cDCs). DCs instruct Th-cell polarization program into specific effector Th subset, which will dictate the type of immune responses. Hence, it is important to unravel how differentiation and/or activation of DC are linked with Th-cell-intrinsic mechanism that directs differentiation toward a specific effector Th subset. Here, we show that loss of Runx/Cbfβ transcription factors complexes during DC development leads to loss of CD103CD11b cDC2s and alters characteristics of CD103CD11b cDCs in the intestine, which was accompanied with impaired differentiation of Rorγt Th17 cells and type 3 Rorγt regulatory T cells. We also show that a Runx-binding enhancer in the gene is essential for T cells to integrate cDC-derived signals to induce Rorγt expression. These findings reveal that Runx/Cbfβ complexes play crucial and complementary roles in cDCs and Th cells to shape converging type 3 immune responses.

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