Association of Acute Kidney Injury with Frailty in Elderly Population: a Systematic Review and Meta-analysis

Overview

Journal Ren Fail

Publisher Informa Healthcare

Date 2019 Dec 7

PMID 31809623

Citations 19

Authors

Zhu Liduzi Jiesisibieke

Tao-Hsin Tung

Qin-Yi Xu

Pei-En Chen

Shih-Yung Hsu

Yongguang Liu

Ching-Wen Chien

Affiliations

Soon will be listed here.

Abstract

The objective of this study was to assess whether an elderly patient's frailty was associated with acute kidney injury (AKI) and to examine whether severe frailty group had an increased risk of AKI than mild-moderate group. We searched The Cochrane Library, PubMed, and EMBASE for relevant studies without language limitations before 1 March 2019 with a priori defined inclusion and exclusion criteria. Five population-based cohort studies were included for systematic review and meta-analysis. Compared with the control group, the frailty group is significantly associated AKI (Odds Ratio = 2.05; 95% CI: 1.23-3.43). The moderate-severe frailty group has an increased risk of AKI than mild frailty group (Hazard Ratio = 2.87; 95% CI: 1.60-5.17. In conclusion, the available best evidence support an association between frailty and AKI among elder patients, thus relevant interventions should be taken among elderly under potential risk of AKI.

Citing Articles

Frailty and chronic diseases: A bi-directional relationship.

Bhattarai U, Bashyal B, Shrestha A, Koirala B, Sharma S Aging Med (Milton). 2024; 7(4):510-515.

PMID: 39234207 PMC: 11369349. DOI: 10.1002/agm2.12349.

Association between frailty and acute kidney injury after cardiac surgery: unraveling the moderation effect of body fat through an international, retrospective, multicohort study.

Bai Y, Wang Z, Lv Y, Liu J, Xu Z, Feng Y Int J Surg. 2024; 111(1):761-770.

PMID: 38954672 PMC: 11745703. DOI: 10.1097/JS9.0000000000001861.

Preoperative geriatric nutritional risk index and neutrophil-to-lymphocyte ratio relate to postoperative acute kidney injury in elderly patients undergoing laparoscopic abdominal surgery.

Ren H, Zhu M, Yu H, Weng Y, Yu W Food Nutr Res. 2024; 68.

PMID: 38868623 PMC: 11167701. DOI: 10.29219/fnr.v68.10564.

A clinical score to predict recovery in end-stage kidney disease due to acute kidney injury.

Shah S, Ng J, Leonard A, Harrison K, Meganathan K, Christianson A Clin Kidney J. 2024; 17(5):sfae085.

PMID: 38726213 PMC: 11079670. DOI: 10.1093/ckj/sfae085.

The Association of Intraindividual Difference Between Cystatin- and Creatinine-Based Estimated GFR and Contrast-Associated Acute Kidney Injury.

Zhang L, Luo M, Zeng J, You Z, Chen L, Chen J Clin Interv Aging. 2024; 19:411-420.

PMID: 38476830 PMC: 10929563. DOI: 10.2147/CIA.S447042.

References

Clegg A, Young J, Iliffe S, Rikkert M, Rockwood K . Frailty in elderly people. Lancet. 2013; 381(9868):752-62. PMC: 4098658. DOI: 10.1016/S0140-6736(12)62167-9. View

Abdel-Kader K, Palevsky P . Acute kidney injury in the elderly. Clin Geriatr Med. 2009; 25(3):331-58. PMC: 2748997. DOI: 10.1016/j.cger.2009.04.001. View

Chi C, Chen T, Wang S, Tung T . Risk of Suicidality in People with Psoriasis: A Systematic Review and Meta-Analysis of Cohort Studies. Am J Clin Dermatol. 2017; 18(5):621-627. DOI: 10.1007/s40257-017-0281-1. View

Joseph B, Phelan H, Hassan A, Jokar T, OKeeffe T, Azim A . The impact of frailty on failure-to-rescue in geriatric trauma patients: A prospective study. J Trauma Acute Care Surg. 2016; 81(6):1150-1155. DOI: 10.1097/TA.0000000000001250. View

Coca S . Acute kidney injury in elderly persons. Am J Kidney Dis. 2010; 56(1):122-31. PMC: 2902696. DOI: 10.1053/j.ajkd.2009.12.034. View

Makris K, Spanou L . Acute Kidney Injury: Definition, Pathophysiology and Clinical Phenotypes. Clin Biochem Rev. 2017; 37(2):85-98. PMC: 5198510. View

Chi C, Wang S, Kirtschig G . Safety of Topical Corticosteroids in Pregnancy. JAMA Dermatol. 2016; 152(8):934-5. DOI: 10.1001/jamadermatol.2016.1009. View

Byrt T . How good is that agreement?. Epidemiology. 1996; 7(5):561. DOI: 10.1097/00001648-199609000-00030. View

Cornell J, Mulrow C, Localio R, Stack C, Meibohm A, Guallar E . Random-effects meta-analysis of inconsistent effects: a time for change. Ann Intern Med. 2014; 160(4):267-70. DOI: 10.7326/M13-2886. View

10.

Morton S, Isted A, Avery P, Wang J . Is Frailty a Predictor of Outcomes in Elderly Inpatients with Acute Kidney Injury? A Prospective Cohort Study. Am J Med. 2018; 131(10):1251-1256.e2. DOI: 10.1016/j.amjmed.2018.03.012. View

11.

Koulouridis I, Price L, Madias N, Jaber B . Hospital-acquired acute kidney injury and hospital readmission: a cohort study. Am J Kidney Dis. 2014; 65(2):275-82. PMC: 6556889. DOI: 10.1053/j.ajkd.2014.08.024. View

12.

McDermid R, Stelfox H, Bagshaw S . Frailty in the critically ill: a novel concept. Crit Care. 2011; 15(1):301. PMC: 3222010. DOI: 10.1186/cc9297. View

13.

Kanauchi M, Kubo A, Kanauchi K, Saito Y . Frailty, health-related quality of life and mental well-being in older adults with cardiometabolic risk factors. Int J Clin Pract. 2008; 62(9):1447-51. DOI: 10.1111/j.1742-1241.2008.01830.x. View

14.

Doi S, Barendregt J, Khan S, Thalib L, Williams G . Advances in the meta-analysis of heterogeneous clinical trials I: The inverse variance heterogeneity model. Contemp Clin Trials. 2015; 45(Pt A):130-8. DOI: 10.1016/j.cct.2015.05.009. View

15.

Pel-Littel R, Schuurmans M, Emmelot-Vonk M, Verhaar H . Frailty: defining and measuring of a concept. J Nutr Health Aging. 2009; 13(4):390-4. DOI: 10.1007/s12603-009-0051-8. View

16.

Odden M, Shlipak M, Tager I . Serum creatinine and functional limitation in elderly persons. J Gerontol A Biol Sci Med Sci. 2009; 64(3):370-6. PMC: 2655007. DOI: 10.1093/gerona/gln037. View

17.

Ortiz-Soriano V, Neyra J . The impact of acute kidney injury on frailty status in critical illness survivors-is there enough evidence?. J Emerg Crit Care Med. 2019; 2. PMC: 6338438. DOI: 10.21037/jeccm.2018.10.17. View

18.

Afilalo J, Karunananthan S, Eisenberg M, Alexander K, Bergman H . Role of frailty in patients with cardiovascular disease. Am J Cardiol. 2009; 103(11):1616-21. DOI: 10.1016/j.amjcard.2009.01.375. View

19.

Chi C, Wang S, Wojnarowska F, Kirtschig G, Davies E, Bennett C . Safety of topical corticosteroids in pregnancy. Cochrane Database Syst Rev. 2015; (10):CD007346. PMC: 8558096. DOI: 10.1002/14651858.CD007346.pub3. View

20.

Ng T, Feng L, Nyunt M, Feng L, Niti M, Tan B . Nutritional, Physical, Cognitive, and Combination Interventions and Frailty Reversal Among Older Adults: A Randomized Controlled Trial. Am J Med. 2015; 128(11):1225-1236.e1. DOI: 10.1016/j.amjmed.2015.06.017. View