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Acute Kidney Injury in Elderly Persons

Overview
Journal Am J Kidney Dis
Specialty Nephrology
Date 2010 Mar 30
PMID 20346560
Citations 92
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Abstract

The incidence rate of acute kidney injury (AKI) is highest in elderly patients, who make up an ever-growing segment of the population at large. AKI in these patients is associated with an increased risk of short- and long-term death and chronic kidney disease, including end-stage renal disease. Whether AKI in older individuals carries a larger relative risk for these outcomes compared with younger individuals is unclear at this time. Other domains, such as health-related quality of life, may be mildly impacted on after an episode of AKI. No effective therapies for AKI currently are available for widespread use. However, because the incidence of AKI is highest in the elderly and the phenotype is not discernibly different from AKI in all populations, future randomized controlled trials of interventions for AKI should be performed in the elderly population.

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References
1.
Vaidya V, Waikar S, Ferguson M, Collings F, Sunderland K, Gioules C . Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans. Clin Transl Sci. 2009; 1(3):200-8. PMC: 2638059. DOI: 10.1111/j.1752-8062.2008.00053.x. View

2.
Qiao X, Chen X, Wu D, Ding R, Wang J, Hong Q . Mitochondrial pathway is responsible for aging-related increase of tubular cell apoptosis in renal ischemia/reperfusion injury. J Gerontol A Biol Sci Med Sci. 2005; 60(7):830-9. DOI: 10.1093/gerona/60.7.830. View

3.
Rowe J, SHOCK N, DeFronzo R . The influence of age on the renal response to water deprivation in man. Nephron. 1976; 17(4):270-8. DOI: 10.1159/000180731. View

4.
Noble J, Simpson K, Allison M . Long-term quality of life and hospital mortality in patients treated with intermittent or continuous hemodialysis for acute renal and respiratory failure. Ren Fail. 2006; 28(4):323-30. DOI: 10.1080/08860220600591487. View

5.
Chertow G, Burdick E, Honour M, Bonventre J, Bates D . Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol. 2005; 16(11):3365-70. DOI: 10.1681/ASN.2004090740. View