AC Electrothermal Effect in Microfluidics: A Review

Overview

Journal Micromachines (Basel)

Publisher MDPI

Date 2019 Nov 14

PMID 31717932

Citations 10

Authors

Alinaghi Salari

Maryam Navi

Thomas Lijnse

Colin Dalton

Affiliations

Soon will be listed here.

Abstract

The electrothermal effect has been investigated extensively in microfluidics since the 1990s and has been suggested as a promising technique for fluid manipulations in lab-on-a-chip devices. The purpose of this article is to provide a timely overview of the previous works conducted in the AC electrothermal field to provide a comprehensive reference for researchers new to this field. First, electrokinetic phenomena are briefly introduced to show where the electrothermal effect stands, comparatively, versus other mechanisms. Then, recent advances in the electrothermal field are reviewed from different aspects and categorized to provide a better insight into the current state of the literature. Results and achievements of different studies are compared, and recommendations are made to help researchers weigh their options and decide on proper configuration and parameters.

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References

Sridharan S, Zhu J, Hu G, Xuan X . Joule heating effects on electroosmotic flow in insulator-based dielectrophoresis. Electrophoresis. 2011; 32(17):2274-81. DOI: 10.1002/elps.201100011. View

Wang X, Cheng C, Wang S, Liu S . Electroosmotic pumps and their applications in microfluidic systems. Microfluid Nanofluidics. 2010; 6(2):145. PMC: 2756694. DOI: 10.1007/s10404-008-0399-9. View

Li S, Ren Y, Cui H, Yuan Q, Wu J, Eda S . Alternating current electrokinetics enhanced in situ capacitive immunoassay. Electrophoresis. 2014; 36(3):471-4. DOI: 10.1002/elps.201400284. View

Green N, Ramos A, Gonzalez A, Morgan H, Castellanos A . Fluid flow induced by nonuniform ac electric fields in electrolytes on microelectrodes. III. Observation of streamlines and numerical simulation. Phys Rev E Stat Nonlin Soft Matter Phys. 2002; 66(2 Pt 2):026305. DOI: 10.1103/PhysRevE.66.026305. View

Feldman H, Sigurdson M, Meinhart C . AC electrothermal enhancement of heterogeneous assays in microfluidics. Lab Chip. 2007; 7(11):1553-9. DOI: 10.1039/b706745c. View

Yang J, Huang Y, Wang X, Becker F, Gascoyne P . Differential analysis of human leukocytes by dielectrophoretic field-flow-fractionation. Biophys J. 2000; 78(5):2680-9. PMC: 1300857. DOI: 10.1016/S0006-3495(00)76812-3. View

Sasaki N, Kitamori T, Kim H . Fluid mixing using AC electrothermal flow on meandering electrodes in a microchannel. Electrophoresis. 2012; 33(17):2668-73. DOI: 10.1002/elps.201200099. View

Ren Q . Investigation of pumping mechanism for non-Newtonian blood flow with AC electrothermal forces in a microchannel by hybrid boundary element method and immersed boundary-lattice Boltzmann method. Electrophoresis. 2018; 39(11):1329-1338. DOI: 10.1002/elps.201700494. View

Williams S . Enhanced electrothermal pumping with thin film resistive heaters. Electrophoresis. 2013; 34(9-10):1400-8. DOI: 10.1002/elps.201200377. View

10.

Salari A, Dalton C . Simultaneous Pumping and Mixing of Biological Fluids in a Double-Array Electrothermal Microfluidic Device. Micromachines (Basel). 2019; 10(2). PMC: 6413218. DOI: 10.3390/mi10020092. View

11.

Ramos A, Gonzalez A, Castellanos A, Green N, Morgan H . Pumping of liquids with ac voltages applied to asymmetric pairs of microelectrodes. Phys Rev E Stat Nonlin Soft Matter Phys. 2003; 67(5 Pt 2):056302. DOI: 10.1103/PhysRevE.67.056302. View

12.

Velasco V, Williams S . Electrokinetic concentration, patterning, and sorting of colloids with thin film heaters. J Colloid Interface Sci. 2013; 394:598-603. DOI: 10.1016/j.jcis.2012.11.066. View

13.

Hadjiaghaie Vafaie R, Ghavifekr H, van Lintel H, Brugger J, Renaud P . Bi-directional ACET micropump for on-chip biological applications. Electrophoresis. 2016; 37(5-6):719-26. DOI: 10.1002/elps.201500404. View

14.

Wu Y, Ren Y, Jiang H . Enhanced model-based design of a high-throughput three dimensional micromixer driven by alternating-current electrothermal flow. Electrophoresis. 2016; 38(2):258-269. DOI: 10.1002/elps.201600106. View

15.

Huang Y, Yang J, Wang X, Becker F, Gascoyne P . The removal of human breast cancer cells from hematopoietic CD34+ stem cells by dielectrophoretic field-flow-fractionation. J Hematother Stem Cell Res. 2000; 8(5):481-90. PMC: 2726259. DOI: 10.1089/152581699319939. View

16.

Williams S, Green N . Electrothermal pumping with interdigitated electrodes and resistive heaters. Electrophoresis. 2015; 36(15):1681-9. DOI: 10.1002/elps.201500112. View

17.

Storey B, Edwards L, Kilic M, Bazant M . Steric effects on ac electro-osmosis in dilute electrolytes. Phys Rev E Stat Nonlin Soft Matter Phys. 2008; 77(3 Pt 2):036317. DOI: 10.1103/PhysRevE.77.036317. View

18.

Pethig R . Review article-dielectrophoresis: status of the theory, technology, and applications. Biomicrofluidics. 2010; 4(2). PMC: 2917862. DOI: 10.1063/1.3456626. View

19.

Schnelle T, Muller T, Fiedler S, Shirley S, Ludwig K, Herrmann A . Trapping of viruses in high-frequency electric field cages. Naturwissenschaften. 1996; 83(4):172-6. DOI: 10.1007/BF01143058. View

20.

Lu Y, Liu T, Lamanda A, Sin M, Gau V, Liao J . AC Electrokinetics of Physiological Fluids for Biomedical Applications. J Lab Autom. 2014; 20(6):611-20. PMC: 4881301. DOI: 10.1177/2211068214560904. View