MiR-125b but Not MiR-125a is Upregulated and Exhibits a Trend to Correlate with Enhanced Disease Severity, Inflammation, and Increased Mortality in Sepsis Patients

Overview

Journal J Clin Lab Anal

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
Pathology

Date 2019 Nov 8

PMID 31696556

Citations 14

Authors

Xiaoping Zhu

Affiliations

Soon will be listed here.

Abstract

Objective: This study aimed to investigate the correlation of miR-125a/b expressions with disease risk, progression, and prognosis of sepsis.

Methods: MiR-125a/b expressions and inflammatory cytokines were detected by RT-qPCR and ELISA assays in plasma samples from 120 sepsis patients. Besides, blood biochemical indexes, disease severity scores, and in-hospital mortality of sepsis patients were recorded. Meanwhile, miR-125a/b expressions in plasma from 120 health controls (HCs) were also detected by RT-qPCR.

Results: MiR-125b was elevated in sepsis patients compared with HCs, and ROC curve revealed that miR-125b could well distinguish sepsis patients from HCs with AUC 0.658. MiR-125b positively correlated with APACHE II score, SOFA score, Scr, CRP, PCT, TNF-α, and IL-6 levels. Most interestingly, miR-125b was greatly decreased in survivors compared with non-survivors, and multivariate analysis revealed that miR-125b independently predicted higher mortality risk in sepsis patients. Besides, miR-125a showed no significant correlation with sepsis risk, disease severity, or prognosis.

Conclusion: MiR-125b but not miR-125a is upregulated and exhibits a trend to correlate with enhanced disease severity, inflammation, and increased mortality in sepsis patients.

Citing Articles

The Diagnostic Utility of Host RNA Biosignatures in Adult Patients With Sepsis: A Systematic Review and Meta-Analysis.

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Prognostic implication of downregulated exosomal miRNAs in patients with sepsis: a cross-sectional study with bioinformatics analysis.

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The Intricate Role of Non-Coding RNAs in Sepsis-Associated Disseminated Intravascular Coagulation.

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Expression of MicroRNAs in Sepsis-Related Organ Dysfunction: A Systematic Review.

Maiese A, Scatena A, Costantino A, Chiti E, Occhipinti C, La Russa R Int J Mol Sci. 2022; 23(16).

PMID: 36012630 PMC: 9409129. DOI: 10.3390/ijms23169354.

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