Regulatory Role of Non-Coding RNAs on Immune Responses During Sepsis

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2021 Dec 27

PMID 34956235

Citations 21

Authors

Soudeh Ghafouri-Fard

Tayyebeh Khoshbakht

Bashdar Mahmud Hussen

Mohammad Taheri

Normohammad Arefian

Affiliations

Soon will be listed here.

Abstract

Sepsis is resulted from a systemic inflammatory response to bacterial, viral, or fungal agents. The induced inflammatory response by these microorganisms can lead to multiple organ system failure with devastating consequences. Recent studies have shown altered expressions of several non-coding RNAs such as long non-coding RNAs (lncRNAs), microRNAs (miRNAs) and circular RNAs (circRNAs) during sepsis. These transcripts have also been found to participate in the pathogenesis of multiple organ system failure through different mechanisms. NEAT1, MALAT1, THRIL, XIST, MIAT and TUG1 are among lncRNAs that participate in the pathoetiology of sepsis-related complications. miR-21, miR-155, miR-15a-5p, miR-494-3p, miR-218, miR-122, miR-208a-5p, miR-328 and miR-218 are examples of miRNAs participating in these complications. Finally, tens of circRNAs such as circC3P1, hsa_circRNA_104484, hsa_circRNA_104670 and circVMA21 and circ-PRKCI have been found to affect pathogenesis of sepsis. In the current review, we describe the role of these three classes of noncoding RNAs in the pathoetiology of sepsis-related complications.

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References

Li M, Zhang Z, Liu B, Chen L, Wang M . LncRNA GAS5 upregulates miR-214 through methylation to participate in cell apoptosis of sepsis. Arch Physiol Biochem. 2020; 128(5):1259-1264. DOI: 10.1080/13813455.2020.1764051. View

Zhang H, Li L, Xu L, Zheng Y . Clinical Significance of the Serum lncRNA NORAD Expression in Patients with Neonatal Sepsis and Its Association with miR-410-3p. J Inflamm Res. 2021; 14:4181-4188. PMC: 8405162. DOI: 10.2147/JIR.S315985. View

Wang Y, Wang H, Zhang C, Zhang C, Yang H, Gao R . Plasma Hsa-miR-92a-3p in correlation with lipocalin-2 is associated with sepsis-induced coagulopathy. BMC Infect Dis. 2020; 20(1):155. PMC: 7031893. DOI: 10.1186/s12879-020-4853-y. View

Xu H, Liu X, Ni H . Clinical significance of miR-19b-3p in patients with sepsis and its regulatory role in the LPS-induced inflammatory response. Eur J Med Res. 2020; 25(1):9. PMC: 7079357. DOI: 10.1186/s40001-020-00408-3. View

Chen Y, Fu Y, Song Y, Li N . Increased Expression of lncRNA UCA1 and HULC Is Required for Pro-inflammatory Response During LPS Induced Sepsis in Endothelial Cells. Front Physiol. 2019; 10:608. PMC: 6558422. DOI: 10.3389/fphys.2019.00608. View

Gao H, Ma H, Gao M, Chen A, Zha S, Yan J . Long non-coding RNA GAS5 aggravates myocardial depression in mice with sepsis via the microRNA-449b/HMGB1 axis and the NF-κB signaling pathway. Biosci Rep. 2021; 41(4). PMC: 8035624. DOI: 10.1042/BSR20201738. View

Wu S, Zhang H, Wu W, Wu Y . [Value of serum miR-21-3p in predicting acute kidney injury in children with sepsis]. Zhongguo Dang Dai Er Ke Za Zhi. 2020; 22(3):269-273. PMC: 7389592. View

Jia P, Wu X, Dai Y, Teng J, Fang Y, Hu J . MicroRNA-21 Is Required for Local and Remote Ischemic Preconditioning in Multiple Organ Protection Against Sepsis. Crit Care Med. 2017; 45(7):e703-e710. DOI: 10.1097/CCM.0000000000002363. View

Shi C, Zhao Y, Li Q, Li J . lncRNA SNHG14 Plays a Role in Sepsis-Induced Acute Kidney Injury by Regulating miR-93. Mediators Inflamm. 2021; 2021:5318369. PMC: 7806393. DOI: 10.1155/2021/5318369. View

10.

Wang H, Meng K, Chen W, Feng D, Jia Y, Xie L . Serum miR-574-5p: a prognostic predictor of sepsis patients. Shock. 2012; 37(3):263-7. DOI: 10.1097/SHK.0b013e318241baf8. View

11.

Luo N, Gao H, Wang Y, Li H, Li Y . MiR-942-5p alleviates septic acute kidney injury by targeting FOXO3. Eur Rev Med Pharmacol Sci. 2020; 24(11):6237-6244. DOI: 10.26355/eurrev_202006_21521. View

12.

Chen X, Song D . LPS promotes the progression of sepsis by activation of lncRNA HULC/miR-204-5p/TRPM7 network in HUVECs. Biosci Rep. 2020; 40(6). PMC: 7295636. DOI: 10.1042/BSR20200740. View

13.

Liu W, Geng F, Yu L . Long non-coding RNA MALAT1/microRNA 125a axis presents excellent value in discriminating sepsis patients and exhibits positive association with general disease severity, organ injury, inflammation level, and mortality in sepsis patients. J Clin Lab Anal. 2020; 34(6):e23222. PMC: 7307338. DOI: 10.1002/jcla.23222. View

14.

Liu Y, Xiao J, Sun J, Chen W, Wang S, Fu R . ATG7 promotes autophagy in sepsis‑induced acute kidney injury and is inhibited by miR‑526b. Mol Med Rep. 2020; 21(5):2193-2201. PMC: 7115197. DOI: 10.3892/mmr.2020.11001. View

15.

Jia Y, Li Z, Cai W, Xiao D, Han S, Han F . SIRT1 regulates inflammation response of macrophages in sepsis mediated by long noncoding RNA. Biochim Biophys Acta Mol Basis Dis. 2017; 1864(3):784-792. DOI: 10.1016/j.bbadis.2017.12.029. View

16.

Lin Z, Liu Z, Wang X, Qiu C, Zheng S . MiR-21-3p Plays a Crucial Role in Metabolism Alteration of Renal Tubular Epithelial Cells during Sepsis Associated Acute Kidney Injury via AKT/CDK2-FOXO1 Pathway. Biomed Res Int. 2019; 2019:2821731. PMC: 6541977. DOI: 10.1155/2019/2821731. View

17.

Xiao T, Sun C, Xiao Y, Li Y . lncRNA NEAT1 mediates sepsis progression by regulating Irak2 via sponging miR-370-3p. Biol Open. 2020; 9(6). PMC: 7327994. DOI: 10.1242/bio.049353. View

18.

Wang W, Li Y, Zhi S, Li J, Miao J, Ding Z . LncRNA-ROR/microRNA-185-3p/YAP1 axis exerts function in biological characteristics of osteosarcoma cells. Genomics. 2020; 113(1 Pt 2):450-461. DOI: 10.1016/j.ygeno.2020.09.009. View

19.

Zheng G, Qu H, Li F, Ma W, Yang H . Propofol attenuates sepsis-induced acute kidney injury by regulating miR-290-5p/CCL-2 signaling pathway. Braz J Med Biol Res. 2018; 51(11):e7655. PMC: 6190213. DOI: 10.1590/1414-431X20187655. View

20.

Sheng B, Zhao L, Zang X, Zhen J, Chen W . miR-375 ameliorates sepsis by downregulating miR-21 level via inhibiting JAK2-STAT3 signaling. Biomed Pharmacother. 2016; 86:254-261. DOI: 10.1016/j.biopha.2016.11.147. View