Halogenating Enzymes for Active Agent Synthesis: First Steps Are Done and Many Have to Follow

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2019 Nov 8

PMID 31694313

Citations 13

Authors

Alexander Veljko Fejzagic

Jan Gebauer

Nikolai Huwa

Thomas Classen

Affiliations

Soon will be listed here.

Abstract

Halogens can be very important for active agents as vital parts of their binding mode, on the one hand, but are on the other hand instrumental in the synthesis of most active agents. However, the primary halogenating compound is molecular chlorine which has two major drawbacks, high energy consumption and hazardous handling. Nature bypassed molecular halogens and evolved at least six halogenating enzymes: Three kind of haloperoxidases, flavin-dependent halogenases as well as α-ketoglutarate and adenosylmethionine (SAM)-dependent halogenases. This review shows what is known today on these enzymes in terms of biocatalytic usage. The reader may understand this review as a plea for the usage of halogenating enzymes for fine chemical syntheses, but there are many steps to take until halogenating enzymes are reliable, flexible, and sustainable catalysts for halogenation.

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