The Story: Characterization and Cloning of the First Tumor Suppressor Gene

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2019 Nov 6

PMID 31683923

Citations 21

Authors

Jesse L Berry

Ashley Polski

Webster K Cavenee

Thaddeus P Dryja

A Linn Murphree

Brenda L Gallie

Affiliations

Soon will be listed here.

Abstract

The gene is the first described human tumor suppressor gene and plays an integral role in the development of retinoblastoma, a pediatric malignancy of the eye. Since its discovery, the stepwise characterization and cloning of have laid the foundation for numerous advances in the understanding of tumor suppressor genes, retinoblastoma tumorigenesis, and inheritance. Knowledge of led to a paradigm shift in the field of cancer genetics, including widespread acceptance of the concept of tumor suppressor genes, and has provided crucial diagnostic and prognostic information through genetic testing for patients affected by retinoblastoma. This article reviews the long history of gene research, characterization, and cloning, and also discusses recent advances in retinoblastoma genetics that have grown out of this foundational work.

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