High-energy Visible Light at Ambient Doses and Intensities Induces Oxidative Stress of Skin-Protective Effects of the Antioxidant and Nrf2 Inducer Licochalcone A in Vitro and in Vivo

Overview

Journal Photodermatol Photoimmunol Photomed

Specialties Allergy & Immunology
Dermatology

Date 2019 Oct 30

PMID 31661571

Citations 18

Authors

Tobias Mann

Kerstin Eggers

Frank Rippke

Mirko Tesch

Anette Buerger

Maxim E Darvin

Sabine Schanzer

Martina C Meinke

Jurgen Lademann

Ludger Kolbe

Affiliations

Soon will be listed here.

Abstract

Background: Solar radiation causes skin damage through the generation of reactive oxygen species (ROS). While UV filters effectively reduce UV-induced ROS, they cannot prevent VIS-induced (400-760 nm) oxidative stress. Therefore, potent antioxidants are needed as additives to sunscreen products.

Methods: We investigated VIS-induced ROS formation and the photoprotective effects of the Nrf2 inducer Licochalcone A (LicA).

Results: Visible spectrum of 400-500 nm dose-dependently induced ROS in cultured human fibroblasts at doses equivalent to 1 hour of sunshine on a sunny summer day (150 J/cm ). A pretreatment for 24 hours with 1 µmol/L LicA reduced ROS formation to the level of unirradiated cells while UV filters alone were ineffective, even at SPF50+. In vivo, topical treatment with a LicA-containing SPF50 + formulation significantly prevented the depletion of intradermal carotenoids by VIS irradiation while SPF50 + control did not protect.

Conclusion: LicA may be a useful additive antioxidant for sunscreens.

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