Premature Birth Impacts Bolus Size and Shape Through Nursing in Infant Pigs

Overview

Journal Pediatr Res

Specialties Biology
Pediatrics

Date 2019 Oct 24

PMID 31645052

Citations 20

Authors

Christopher J Mayerl

Alexis M Myrla

Laura E Bond

Bethany M Stricklen

Rebecca Z German

Francois D H Gould

Affiliations

Soon will be listed here.

Abstract

Background: The formation of a bolus of food is critical for proper feeding function, and there is substantial variation in the size and shape of a bolus prior to a swallow. Preterm infants exhibit decreased abilities to acquire and process food, but how that relates to their bolus size and shape is unknown. Here, we test two hypotheses: (1) that bolus size and shape will differ between term and preterm infants, and (2) bolus size and shape will change longitudinally through development in both term and preterm infants.

Methods: To test these hypotheses, we measured bolus size and shape in preterm and term infant pigs longitudinally through nursing using high-speed videofluoroscopy.

Results: Preterm infant pigs swallowed smaller volumes of milk. Although term infants increased the amount of milk per swallow as they aged, preterm infants did not. These changes in bolus volume were also correlated with changes in bolus shape; larger boluses became more elongate as they better filled the available anatomical space of the valleculae.

Conclusions: These results suggest that preterm birth reduces the ability of preterm pigs to increase bolus size as they grow, affecting development in this fragile population. These results highlight that studies on term infant feeding may not translate to preterm infants.

Citing Articles

A Ducted, Biomimetic Nipple Improves Aspects of Infant Feeding Physiology and Performance in an Animal Model.

Mayerl C, Kaczmarek E, Smith A, Shideler H, Blilie M, Edmonds C Dysphagia. 2024; .

PMID: 39487856 DOI: 10.1007/s00455-024-10780-5.

The effects of simulated gastroesophageal reflux on infant pig oropharyngeal feeding physiology.

Edmonds C, Robbins K, Dvorak E, Howe S, Sheldon S, Mayerl C Am J Physiol Gastrointest Liver Physiol. 2024; 327(1):G105-G116.

PMID: 38772905 PMC: 11376974. DOI: 10.1152/ajpgi.00027.2024.

The Impact of Varying Nipple Properties on Infant Feeding Physiology and Performance Throughout Ontogeny in a Validated Animal Model.

Steer K, Johnson M, Edmonds C, Adjerid K, Bond L, German R Dysphagia. 2023; 39(3):460-467.

PMID: 37947879 PMC: 11181904. DOI: 10.1007/s00455-023-10630-w.

Evolution, diversification and function of the maternal-infant dyad in mammalian feeding.

Mayerl C, German R Philos Trans R Soc Lond B Biol Sci. 2023; 378(1891):20220554.

PMID: 37839443 PMC: 10577036. DOI: 10.1098/rstb.2022.0554.

Impact of volume and rate of milk delivery on coordination of respiration and swallowing in infant pigs.

Gould F, Mayerl C, Adjerid K, Edmonds C, Charles N, Johnson M J Exp Zool A Ecol Integr Physiol. 2023; 339(10):1052-1058.

PMID: 37653670 PMC: 11321598. DOI: 10.1002/jez.2754.

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