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BE-PIGS: a Base-editing Tool with Deaminases Inlaid into Cas9 PI Domain Significantly Expanded the Editing Scope

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Date 2019 Oct 23
PMID 31637015
Citations 22
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References
1.
Huang T, Zhao K, Miller S, Gaudelli N, Oakes B, Fellmann C . Author Correction: Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors. Nat Biotechnol. 2019; 37(7):820. DOI: 10.1038/s41587-019-0168-1. View

2.
Jiang W, Feng S, Huang S, Yu W, Li G, Yang G . BE-PLUS: a new base editing tool with broadened editing window and enhanced fidelity. Cell Res. 2018; 28(8):855-861. PMC: 6082914. DOI: 10.1038/s41422-018-0052-4. View

3.
Anders C, Niewoehner O, Duerst A, Jinek M . Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease. Nature. 2014; 513(7519):569-73. PMC: 4176945. DOI: 10.1038/nature13579. View

4.
Komor A, Zhao K, Packer M, Gaudelli N, Waterbury A, Koblan L . Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity. Sci Adv. 2017; 3(8):eaao4774. PMC: 5576876. DOI: 10.1126/sciadv.aao4774. View

5.
Komor A, Badran A, Liu D . Editing the Genome Without Double-Stranded DNA Breaks. ACS Chem Biol. 2017; 13(2):383-388. PMC: 5891729. DOI: 10.1021/acschembio.7b00710. View