Prolonged Survival in a Patient with a Cervical Spine H3K27M-mutant Diffuse Midline Glioma

Overview

Journal BMJ Case Rep

Specialty General Medicine

Date 2019 Oct 20

PMID 31628092

Citations 6

Authors

Kelsey Peters

Drew Pratt

Carl Koschmann

Denise Leung

Affiliations

Soon will be listed here.

Abstract

We report a case of prolonged survival in a patient with known cervical intramedullary H3K27M-mutant diffuse midline glioma. A 39-year-old man presented for evaluation with several months of progressive upper extremity pain and weakness. MRI of the cervical spine revealed an intramedullary ring-enhancing lesion centred at C3-C4. Following subtotal surgical resection, a diagnosis of glioblastoma (GBM) was confirmed. Subsequent testing at a later date revealed an H3K27M mutation. He was initially treated with radiation and concomitant and adjuvant temozolomide. He had multiply recurrent disease and was treated with various regimens, including the histone deacetylase inhibitor valproic acid. The patient passed away 31 months (~2.5 years) after diagnosis. Our case is one of few reported adult spinal cord GBMs possessing the H3K27M mutation, and one with the longest reported overall survival in the literature to date.

Citing Articles

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