Carl Koschmann
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Explore the profile of Carl Koschmann including associated specialties, affiliations and a list of published articles.
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96
Citations
1633
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Recent Articles
1.
Mayr L, Neyazi S, Schwark K, Trissal M, Beck A, Labelle J, et al.
Cancer Cell
. 2025 Mar;
PMID: 40086436
PDGFRA is crucial to tumorigenesis and frequently genomically altered in high-grade glioma (HGG). In a comprehensive dataset of pediatric HGG (n = 261), we detect PDGFRA mutations and/or amplifications in...
2.
Venneti S, Kawakibi A, Ji S, Waszak S, Sweha S, Mota M, et al.
Cancer Discov
. 2025 Mar;
15(3):657.
PMID: 40025951
No abstract available.
3.
Pearson A, Mueller S, Filbin M, Grill J, Hawkins C, Jones C, et al.
Eur J Cancer
. 2025 Jan;
217:115230.
PMID: 39854822
Fewer than 10 % of children with diffuse midline glioma (DMG) survive 2 years from diagnosis. Radiation therapy remains the cornerstone of treatment and there are no medicinal products with...
4.
Erez N, Furth N, Fedyuk V, Wadden J, Aittaleb R, Adam T, et al.
Cell Rep Med
. 2025 Jan;
6(1):101918.
PMID: 39809263
The analysis of cell-free tumor DNA (ctDNA) and proteins in the blood of patients with cancer potentiates a new generation of non-invasive diagnostic approaches. However, confident detection of tumor-originating markers...
5.
Batsios G, Taglang C, Udutha S, Gillespie A, Robinson S, Phoenix T, et al.
bioRxiv
. 2025 Jan;
PMID: 39803472
Statement Of Significance: This study establishes a role for lactate in driving nucleotide biosynthesis in DMGs. Importantly, imaging lactate production from glucose using DMI provides a readout of tumor proliferation...
6.
Pearlman A, Wang Y, Kalluri A, Parker M, Cohen J, Dudley J, et al.
medRxiv
. 2024 Dec;
PMID: 39677487
Statement Of Significance: There is a paucity of technologies beyond surgical biopsy that can accurately diagnose central nervous system neoplasms. We developed a novel, sensitive and highly specific assay that...
7.
Roberts H, Ravi K, Marini B, Schepers A, Kline C, Kilburn L, et al.
J Pediatr Hematol Oncol
. 2024 Nov;
47(1):19-30.
PMID: 39527919
The recent trial Pediatric Neuro-Oncology Consortium 003 (PNOC003) utilized a molecular tumor board to recommend personalized treatment regimens based on tumor sequencing results in children with DIPG. We separately developed...
8.
Guo Y, Li Z, Parsels L, Wang Z, Parsels J, Dalvi A, et al.
bioRxiv
. 2024 Sep;
PMID: 39253432
Background: Radiotherapy (RT) is the primary treatment for diffuse midline glioma (DMG), a lethal pediatric malignancy defined by histone H3 lysine 27-to-methionine (H3K27M) mutation. Based on the loss of H3K27...
9.
Simoneau J, Robertson P, Muraszko K, Maher C, Garton H, Calvert R, et al.
J Natl Compr Canc Netw
. 2024 Sep;
22(7).
PMID: 39236755
Tissue-agnostic, molecularly targeted therapies are becoming increasingly common in cancer treatment. The molecular drivers of some classes and subclasses of tumors are rapidly being uncovered in an era of deep...
10.
Liu I, Cruzeiro G, Bjerke L, Rogers R, Grabovska Y, Beck A, et al.
Cancer Cell
. 2024 Sep;
PMID: 39232581
Diffuse hemispheric gliomas, H3G34R/V-mutant (DHG-H3G34), are lethal brain tumors lacking targeted therapies. They originate from interneuronal precursors; however, leveraging this origin for therapeutic insights remains unexplored. Here, we delineate a...