» Articles » PMID: 31624266

Colonizing Multidrug-resistant Bacteria and the Longitudinal Evolution of the Intestinal Microbiome After Liver Transplantation

Overview
Journal Nat Commun
Specialty Biology
Date 2019 Oct 19
PMID 31624266
Citations 40
Authors
Affiliations
Soon will be listed here.
Abstract

Infections by multidrug-resistant bacteria (MDRB) remain a leading cause of morbidity and mortality after liver transplantation (LT). Gut dysbiosis characteristic of end-stage liver disease may predispose patients to intestinal MDRB colonization and infection, in turn exacerbating dysbiosis. However, relationships between MDRB colonization and dysbiosis after LT remain unclear. We prospectively recruited 177 adult patients undergoing LT at a single tertiary care center. 16 S V3-V4 rRNA sequencing was performed on 723 fecal samples collected pre-LT and periodically until one-year post-LT to test whether MDRB colonization was associated with decreased microbiome diversity. In multivariate linear mixed-effect models, MDRB colonization predicts reduced Shannon α-diversity, after controlling for underlying liver disease, antibiotic exposures, and clinical complications. Importantly, pre-LT microbial markers predict subsequent colonization by MDRB. Our results suggest MDRB colonization as a major, previously unrecognized, marker of persistent dysbiosis. Therapeutic approaches accounting for microbial and clinical factors are needed to address post-transplant microbiome health.

Citing Articles

A critical review of microbiome-derived metabolic functions and translational research in liver diseases.

Ganesan R, Thirumurugan D, Vinayagam S, Kim D, Suk K, Iyer M Front Cell Infect Microbiol. 2025; 15:1488874.

PMID: 40066068 PMC: 11891185. DOI: 10.3389/fcimb.2025.1488874.


Information Extraction from Clinical Texts with Generative Pre-trained Transformer Models.

Kim M, Chung P, Aghaeepour N, Kim N Int J Med Sci. 2025; 22(5):1015-1028.

PMID: 40027192 PMC: 11866537. DOI: 10.7150/ijms.103332.


Carbapenem-Resistant Enterobacteriaceae Colonization or Infection Was Not Associated with Post-Liver Transplant Graft Failure: An Observational Cohort Study.

Caria J, Goncalves A, Cristovao G, Carlos M, Magalhaes S, Almeida V GE Port J Gastroenterol. 2025; 32(1):18-24.

PMID: 39906515 PMC: 11790264. DOI: 10.1159/000539690.


Integrative genomics would strengthen AMR understanding through ONE health approach.

Liu C, Pandey R Heliyon. 2025; 10(14):e34719.

PMID: 39816336 PMC: 11734142. DOI: 10.1016/j.heliyon.2024.e34719.


Gut Microbial Dysbiosis and Implications in Solid Organ Transplantation.

Medina C, Aykut B Biomedicines. 2025; 12(12.

PMID: 39767699 PMC: 11673786. DOI: 10.3390/biomedicines12122792.


References
1.
Klindworth A, Pruesse E, Schweer T, Peplies J, Quast C, Horn M . Evaluation of general 16S ribosomal RNA gene PCR primers for classical and next-generation sequencing-based diversity studies. Nucleic Acids Res. 2012; 41(1):e1. PMC: 3592464. DOI: 10.1093/nar/gks808. View

2.
Moreno R, Berenguer M . Post-liver transplantation medical complications. Ann Hepatol. 2006; 5(2):77-85. View

3.
Sun L, Yang Y, Qu W, Zhu Z, Wei L, Ye Z . Gut microbiota of liver transplantation recipients. Sci Rep. 2017; 7(1):3762. PMC: 5476624. DOI: 10.1038/s41598-017-03476-4. View

4.
Cervera C, van Delden C, Gavalda J, Welte T, Akova M, Carratala J . Multidrug-resistant bacteria in solid organ transplant recipients. Clin Microbiol Infect. 2014; 20 Suppl 7:49-73. DOI: 10.1111/1469-0691.12687. View

5.
Mandal S, Van Treuren W, White R, Eggesbo M, Knight R, Peddada S . Analysis of composition of microbiomes: a novel method for studying microbial composition. Microb Ecol Health Dis. 2015; 26:27663. PMC: 4450248. DOI: 10.3402/mehd.v26.27663. View