Interaction Between Ischemia-reperfusion Injury and Intestinal Microecology in Organ Transplantation and Its Therapeutic Prospects

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2024 Dec 23

PMID 39712022

Authors

Yong-Qi Lian

Peng-Fei Li

Yan Guo

Yan-Lin Tao

Ya-Nan Liu

Zhao-Yu Liang

Shu-Fen Zhu

Affiliations

Soon will be listed here.

Abstract

Organ transplantation is a vital intervention for end-stage organ failure; however, ischemia-reperfusion injury is a complication of transplantation, affecting the prognosis and survival of transplant recipients. As a complex ecosystem, recent research has highlighted the role of the intestinal microecology in transplantation, revealing its significant interplay with ischemia-reperfusion injury. This review explores the interaction between ischemia-reperfusion injury and intestinal microecology, with a special focus on how ischemia-reperfusion injury affects intestinal microecology and how these microecological changes contribute to complications after organ transplantation, such as infection and rejection. Based on a comprehensive analysis of current research advances, this study proposes potential strategies to improve transplant outcomes, offering guidance for future research and clinical practice.

References

Chi X, Yao W, Xia H, Jin Y, Li X, Cai J . Elevation of HO-1 Expression Mitigates Intestinal Ischemia-Reperfusion Injury and Restores Tight Junction Function in a Rat Liver Transplantation Model. Oxid Med Cell Longev. 2015; 2015:986075. PMC: 4441991. DOI: 10.1155/2015/986075. View

Barathan M, Ng S, Lokanathan Y, Ng M, Law J . The Profound Influence of Gut Microbiome and Extracellular Vesicles on Animal Health and Disease. Int J Mol Sci. 2024; 25(7). PMC: 11012031. DOI: 10.3390/ijms25074024. View

Corona D, Ekser B, Gioco R, Caruso M, Schipa C, Veroux P . Heme-Oxygenase and Kidney Transplantation: A Potential for Target Therapy?. Biomolecules. 2020; 10(6). PMC: 7355572. DOI: 10.3390/biom10060840. View

Assimakopoulos S, Eleftheriotis G, Lagadinou M, Karamouzos V, Dousdampanis P, Siakallis G . SARS CoV-2-Induced Viral Sepsis: The Role of Gut Barrier Dysfunction. Microorganisms. 2022; 10(5). PMC: 9143860. DOI: 10.3390/microorganisms10051050. View

Wang J, Kuo C, Kuo F, Wang Y, Hsu W, Yu F . Fecal microbiota transplantation: Review and update. J Formos Med Assoc. 2018; 118 Suppl 1:S23-S31. DOI: 10.1016/j.jfma.2018.08.011. View

Kato K, Nagao M, Miyamoto K, Oka K, Takahashi M, Yamamoto M . Longitudinal Analysis of the Intestinal Microbiota in Liver Transplantation. Transplant Direct. 2017; 3(4):e144. PMC: 5381737. DOI: 10.1097/TXD.0000000000000661. View

Aboelez M, Ezelarab H, Alotaibi G, Elsayed Abouzed D . Inflammatory setting, therapeutic strategies targeting some pro-inflammatory cytokines and pathways in mitigating ischemia/reperfusion-induced hepatic injury: a comprehensive review. Naunyn Schmiedebergs Arch Pharmacol. 2024; 397(9):6299-6315. DOI: 10.1007/s00210-024-03074-y. View

Oh C, Kim M, Lee J, Kim D, Kim I, Park S . Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion. Kidney Int. 2023; 104(4):724-739. DOI: 10.1016/j.kint.2023.06.022. View

Aslam S, Courtwright A, Koval C, Lehman S, Morales S, Furr C . Early clinical experience of bacteriophage therapy in 3 lung transplant recipients. Am J Transplant. 2019; 19(9):2631-2639. PMC: 6711787. DOI: 10.1111/ajt.15503. View

10.

Movahed M, Brockie S, Hong J, Fehlings M . Transcriptomic Hallmarks of Ischemia-Reperfusion Injury. Cells. 2021; 10(7). PMC: 8305649. DOI: 10.3390/cells10071838. View

11.

Wang M, Pan W, Xu Y, Zhang J, Wan J, Jiang H . Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Cardiovascular Diseases. J Inflamm Res. 2022; 15:3083-3094. PMC: 9148574. DOI: 10.2147/JIR.S350109. View

12.

Wiertsema S, van Bergenhenegouwen J, Garssen J, Knippels L . The Interplay between the Gut Microbiome and the Immune System in the Context of Infectious Diseases throughout Life and the Role of Nutrition in Optimizing Treatment Strategies. Nutrients. 2021; 13(3). PMC: 8001875. DOI: 10.3390/nu13030886. View

13.

Haak B, Littmann E, Chaubard J, Pickard A, Fontana E, Adhi F . Impact of gut colonization with butyrate-producing microbiota on respiratory viral infection following allo-HCT. Blood. 2018; 131(26):2978-2986. PMC: 6024637. DOI: 10.1182/blood-2018-01-828996. View

14.

Doycheva I, Leise M, Watt K . The Intestinal Microbiome and the Liver Transplant Recipient: What We Know and What We Need to Know. Transplantation. 2015; 100(1):61-8. DOI: 10.1097/TP.0000000000001008. View

15.

Assimakopoulos S, Bhagani S, Aggeletopoulou I, Tsounis E, Tsochatzis E . The role of gut barrier dysfunction in postoperative complications in liver transplantation: pathophysiological and therapeutic considerations. Infection. 2024; 52(3):723-736. PMC: 11143052. DOI: 10.1007/s15010-024-02182-4. View

16.

Nastos C, Kalimeris K, Papoutsidakis N, Tasoulis M, Lykoudis P, Theodoraki K . Global consequences of liver ischemia/reperfusion injury. Oxid Med Cell Longev. 2014; 2014:906965. PMC: 3995148. DOI: 10.1155/2014/906965. View

17.

Nojima T, Obara T, Yamamoto H, Yumoto T, Igawa T, Aokage T . Luminal administration of biliverdin ameliorates ischemia-reperfusion injury following intestinal transplant in rats. Surgery. 2022; 172(5):1522-1528. DOI: 10.1016/j.surg.2022.07.021. View

18.

McIntosh C, Chen L, Shaiber A, Eren A, Alegre M . Gut microbes contribute to variation in solid organ transplant outcomes in mice. Microbiome. 2018; 6(1):96. PMC: 5968713. DOI: 10.1186/s40168-018-0474-8. View

19.

Neemann K, Eichele D, Smith P, Bociek R, Akhtari M, Freifeld A . Fecal microbiota transplantation for fulminant Clostridium difficile infection in an allogeneic stem cell transplant patient. Transpl Infect Dis. 2012; 14(6):E161-5. DOI: 10.1111/tid.12017. View

20.

Fernandez A, Sanchez-Tarjuelo R, Cravedi P, Ochando J, Lopez-Hoyos M . Review: Ischemia Reperfusion Injury-A Translational Perspective in Organ Transplantation. Int J Mol Sci. 2020; 21(22). PMC: 7696417. DOI: 10.3390/ijms21228549. View