Relationships of Sex Hormone Levels with Activity of Daily Living in Chinese Female Centenarians

Overview

Journal J Nutr Health Aging

Specialties Geriatrics
Nutritional Sciences

Date 2019 Sep 28

PMID 31560034

Citations 4

Authors

S Fu

Y Yao

F Lv

F Zhang

Y Zhao

F Luan

Affiliations

Soon will be listed here.

Abstract

Background: Activity of daily living declines in female elderly, which not only increases hospitalization and mortality rates, but also aggravates individual and societal burden. Large samples are needed to elucidate the relationships of plasma sex hormone levels with activity of daily living in Chinese female centenarians to better understand the effects of hormone-replacing therapy.

Objective: As the first time in the world, the current study was designed to investigate the relationships of plasma sex hormone levels with activity of daily living in Chinese female centenarians.

Participants: China Hainan Centenarian Cohort Study was carried out in 18 cities and counties of Hainan Province.

Main Measures: Home interview, physical examination and blood analysis were carried out in 583 female centenarians following standard procedures. Barthel Index was used to assess the activity of daily living.

Key Results: Median age of all female centenarians was 102 years, with the range from 100 to 115 years. Median values of Barthel Index were 85(60-90). In multivariate linear regression analyses, Barthel Index values were inversely associated with plasma luteinizing hormone (LH), follicle-simulating hormone (FSH), testosterone, progesterone and estradiol levels (P<0.05 for all).

Conclusion: Plasma sex hormone levels, including LH, FSH, testosterone, progesterone and estradiol, had significant relationships with activity of daily living in Chinese female centenarians.

Citing Articles

Sex hormones and physical function among the Chinese oldest-old and centenarian women.

Zhu Q, Ping P, Zhang P, Ning C, Zhao Y, Yao Y J Transl Med. 2022; 20(1):340.

PMID: 35902963 PMC: 9331572. DOI: 10.1186/s12967-022-03539-9.

Centenarian longevity had inverse relationships with nutritional status and abdominal obesity and positive relationships with sex hormones and bone turnover in the oldest females.

Fu S, Ping P, Li Y, Li B, Zhao Y, Yao Y J Transl Med. 2021; 19(1):436.

PMID: 34663361 PMC: 8522151. DOI: 10.1186/s12967-021-03115-7.

Female Fertility Has a Negative Relationship With Longevity in Chinese Oldest-Old Population: A Cross-Sectional Study.

Zhu Q, Fu S, Zhang Q, Tian J, Zhao Y, Yao Y Front Endocrinol (Lausanne). 2021; 11:616207.

PMID: 33613452 PMC: 7887279. DOI: 10.3389/fendo.2020.616207.

Multiple Measures of Mineral Metabolism Were Associated With Renal Function in Chinese Centenarians: A Cross-Sectional Study.

Fu S, Yu H, Li Y, Lv F, Deng J, Zhang F Front Med (Lausanne). 2020; 7:120.

PMID: 32351965 PMC: 7174657. DOI: 10.3389/fmed.2020.00120.

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