Reversible Covalent End-Capping of Collagen Model Peptides

Overview

Journal Chemistry

Specialty Chemistry

Date 2019 Sep 27

PMID 31557356

Citations 3

Authors

Christoph Priem

Armin Geyer

Affiliations

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Abstract

The combination of supramolecular aggregation of collagen model peptides with reversible covalent end-capping of the formed triple helix in a single experimental set-up yielded minicollagens, which were characterized by a single melting temperature. In spite of the numerous possible reaction intermediates, a specific synthetic collagen with a leading, middle and trailing strand is formed in a highly cooperative self-assembly process.

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