Trimerization and Triple Helix Stabilization of the Collagen XIX NC2 Domain

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 2008 Oct 11

PMID 18845531

Citations 18

Authors

Sergei P Boudko

Jurgen Engel

Hans Peter Bachinger

Affiliations

Soon will be listed here.

Abstract

The mechanisms of chain selection and assembly of fibril-associated collagens with interrupted triple helices (FACITs) must differ from that of fibrillar collagens, since they lack the characteristic C-propeptide. We analyzed two carboxyl-terminal noncollagenous domains, NC2 and NC1, of collagen XIX as potential trimerization units and found that NC2 forms a stable trimer and substantially stabilizes a collagen triple helix attached to either end. In contrast, the NC1 domain requires formation of an adjacent collagen triple helix to form interchain disulfide bridges. The NC2 domain of collagen XIX and probably of other FACITs is responsible for chain selection and trimerization.

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