Relationship Between Serum Vitamin D and Calcium Levels and Vitamin D Receptor Gene Polymorphisms in Colorectal Cancer

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2019 Sep 20

PMID 31534963

Citations 14

Authors

Ayat B Al-Ghafari

Khadijah S Balamash

Huda A Al Doghaither

Affiliations

Soon will be listed here.

Abstract

Background: Many epidemiological studies have shown that vitamin D deficiency is associated with various types of human cancers. The biological action of vitamin D and its metabolites is mediated by the transcription factor vitamin D receptor (VDR). The gene is highly expressed in the colon and is involved in many biological functions. The aim of the current study was to assess the relationship between serum vitamin D metabolite and calcium levels with polymorphisms in normal and colorectal cancer (CRC) patients.

Methods: Fifty Saudi CRC patients and fifty controls were enrolled in the study. The levels of total vitamin D, 25(OH)D, and calcium were measured in serum.

Results: The homozygous genotype (aa) of the polymorphism (rs7975232) was found to correlate with total serum vitamin D levels of CRC patients, while the heterozygous (Tt) polymorphism (rs731236) was associated with serum calcium levels. In contrast, the and polymorphisms (rs1544410 and rs2228570, resp.) did not affect the serum levels of total vitamin D, 25-hydroxyvitamin D, and calcium.

Conclusion: Appropriate vitamin D levels were shown to be important in preventing the onset of CRC.

Citing Articles

Role of Vitamin D Receptor (BsmI-VDR) and Insulin Receptor (NsiI-A/G) Gene Polymorphisms in Colorectal Adenoma Susceptibility.

Ciulei G, Orasan O, Cozma A, Negrean V, Para I, Ciumarnean L Int J Mol Sci. 2024; 25(16).

PMID: 39201651 PMC: 11354587. DOI: 10.3390/ijms25168965.

Epidemiology of Colorectal Cancer in Saudi Arabia: A Review.

Alessa A, Khan A Cureus. 2024; 16(7):e64564.

PMID: 39144848 PMC: 11323712. DOI: 10.7759/cureus.64564.

Role of dietary nutrients and metabolism in colorectal cancer.

Ye J, Bao X, Wei J, Zhang Y, Liu Y, Xin L Asia Pac J Clin Nutr. 2024; 33(2):153-161.

PMID: 38794975 PMC: 11170022. DOI: 10.6133/apjcn.202406_33(2).0002.

Relevance of Serum Levels and Functional Genetic Variants in Vitamin D Receptor Gene among Saudi Women with Gestational Diabetes Mellitus.

Ali Khan I, Alhaizan M, Neyazi S, Al-Hakeem M, Alshammary A Nutrients. 2023; 15(19).

PMID: 37836571 PMC: 10574375. DOI: 10.3390/nu15194288.

Vitamin D and Calcium as Key Potential Factors Related to Colorectal Cancer Prevention and Treatment: A Systematic Review.

Cruz-Pierard S, Nestares T, Amaro-Gahete F Nutrients. 2022; 14(22).

PMID: 36432621 PMC: 9692441. DOI: 10.3390/nu14224934.

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