Logical Design of Oral Glucose Ingestion Pattern Minimizing Blood Glucose in Humans

Overview

Journal NPJ Syst Biol Appl

Specialty Biology

Date 2019 Sep 12

PMID 31508240

Citations 6

Authors

Masashi Fujii

Yohei Murakami

Yasuaki Karasawa

Yohei Sumitomo

Suguru Fujita

Masanori Koyama

Shinsuke Uda

Hiroyuki Kubota

Hiroshi Inoue

Katsumi Konishi

Shigeyuki Oba

Shin Ishii

Shinya Kuroda

Affiliations

Soon will be listed here.

Abstract

Excessive increase in blood glucose level after eating increases the risk of macroangiopathy, and a method for not increasing the postprandial blood glucose level is desired. However, a logical design method of the dietary ingestion pattern controlling the postprandial blood glucose level has not yet been established. We constructed a mathematical model of blood glucose control by oral glucose ingestion in three healthy human subjects, and predicted that intermittent ingestion 30 min apart was the optimal glucose ingestion patterns that minimized the peak value of blood glucose level. We confirmed with subjects that this intermittent pattern consistently decreased the peak value of blood glucose level. We also predicted insulin minimization pattern, and found that the intermittent ingestion 30 min apart was optimal, which is similar to that of glucose minimization pattern. Taken together, these results suggest that the glucose minimization is achieved by suppressing the peak value of insulin concentration, rather than by enhancing insulin concentration. This approach could be applied to design optimal dietary ingestion patterns.

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