The Role of Transient Receptor Potential Vanilloid 1 in Common Diseases of the Digestive Tract and the Cardiovascular and Respiratory System

Overview

Journal Front Physiol

Date 2019 Sep 10

PMID 31496955

Citations 54

Authors

Qian Du

Qiushi Liao

Changmei Chen

Xiaoxu Yang

Rui Xie

Jingyu Xu

Affiliations

Soon will be listed here.

Abstract

Transient receptor potential vanilloid subtype 1 (TRPV1), a member of the transient receptor potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely expressed in sensory nerve fibers and nonneuronal cells, including certain vascular endothelial cells and smooth muscle cells. The activation of TRPV1 may be involved in the regulation of various physiological functions, such as the release of inflammatory mediators in the body, gastrointestinal motility function, and temperature regulation. In recent years, a large number of studies have revealed that TRPV1 plays an important role in the physiological and pathological conditions of the digestive system, cardiovascular system, and respiratory system, but there is no systematic report on TRPV1. The objective of this review is to explain the function and effects of TRPV1 on specific diseases, such as irritable bowel syndrome, hypertension, and asthma, and to further investigate the intrinsic relationship between the expression and function of TRPV1 in those diseases to find new therapeutic targets for the cure of related diseases.

Citing Articles

Computational approaches to investigate the relationship between periodontitis and cardiovascular diseases for precision medicine.

Duenas S, McGee Z, Mhatre I, Mayilvahanan K, Patel K, Abdelhalim H Hum Genomics. 2024; 18(1):116.

PMID: 39427205 PMC: 11491019. DOI: 10.1186/s40246-024-00685-7.

Key targets of signal transduction neural mechanisms in acupuncture treatment of cardiovascular diseases: Hypothalamus and autonomic nervous system.

Zhou X, Zhou J, Zhang F, Shu Q, Wu Y, Chang H Heliyon. 2024; 10(19):e38197.

PMID: 39386880 PMC: 11462008. DOI: 10.1016/j.heliyon.2024.e38197.

TRPV1: The key bridge in neuroimmune interactions.

Chen J, Sun W, Zhu Y, Zhao F, Deng S, Tian M J Intensive Med. 2024; 4(4):442-452.

PMID: 39310069 PMC: 11411435. DOI: 10.1016/j.jointm.2024.01.008.

Capsaicin: Emerging Pharmacological and Therapeutic Insights.

Petran E, Periferakis A, Troumpata L, Periferakis A, Scheau A, Badarau I Curr Issues Mol Biol. 2024; 46(8):7895-7943.

PMID: 39194685 PMC: 11352336. DOI: 10.3390/cimb46080468.

Receptors Involved in COVID-19-Related Anosmia: An Update on the Pathophysiology and the Mechanistic Aspects.

Al-Saigh N, Harb A, Abdalla S Int J Mol Sci. 2024; 25(15).

PMID: 39126095 PMC: 11313362. DOI: 10.3390/ijms25158527.

References

Huo Y, Ley K . Role of platelets in the development of atherosclerosis. Trends Cardiovasc Med. 2004; 14(1):18-22. DOI: 10.1016/j.tcm.2003.09.007. View

Wei Z, Wang L, Han J, Song J, Yao L, Shao L . Decreased expression of transient receptor potential vanilloid 1 impaires the postischemic recovery of diabetic mouse hearts. Circ J. 2009; 73(6):1127-32. DOI: 10.1253/circj.cj-08-0945. View

Fuhrer M, Hammer J . Effect of repeated, long term capsaicin ingestion on intestinal chemo- and mechanosensation in healthy volunteers. Neurogastroenterol Motil. 2009; 21(5):521-7, e7. DOI: 10.1111/j.1365-2982.2008.01227.x. View

Alawi K, Keeble J . The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation. Pharmacol Ther. 2009; 125(2):181-95. DOI: 10.1016/j.pharmthera.2009.10.005. View

Marshall N, Liang L, Bodkin J, Dessapt-Baradez C, Nandi M, Collot-Teixeira S . A role for TRPV1 in influencing the onset of cardiovascular disease in obesity. Hypertension. 2012; 61(1):246-52. DOI: 10.1161/HYPERTENSIONAHA.112.201434. View

Xu G, Winston J, Shenoy M, Yin H, Pendyala S, Pasricha P . Transient receptor potential vanilloid 1 mediates hyperalgesia and is up-regulated in rats with chronic pancreatitis. Gastroenterology. 2007; 133(4):1282-92. DOI: 10.1053/j.gastro.2007.06.015. View

Baxter M, Eltom S, Dekkak B, Yew-Booth L, Dubuis E, Maher S . Role of transient receptor potential and pannexin channels in cigarette smoke-triggered ATP release in the lung. Thorax. 2014; 69(12):1080-9. DOI: 10.1136/thoraxjnl-2014-205467. View

Weihe E, Nohr D, Muller S, Buchler M, Friess H, Zentel H . The tachykinin neuroimmune connection in inflammatory pain. Ann N Y Acad Sci. 1991; 632:283-95. DOI: 10.1111/j.1749-6632.1991.tb33116.x. View

Gavva N, Treanor J, Garami A, Fang L, Surapaneni S, Akrami A . Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans. Pain. 2008; 136(1-2):202-10. DOI: 10.1016/j.pain.2008.01.024. View

10.

Hajek A, Lindley A, Favoreto Jr S, Carter R, Schleimer R, Kuperman D . 12/15-Lipoxygenase deficiency protects mice from allergic airways inflammation and increases secretory IgA levels. J Allergy Clin Immunol. 2008; 122(3):633-9.e3. PMC: 2802267. DOI: 10.1016/j.jaci.2008.06.021. View

11.

Okumi H, Tashima K, Matsumoto K, Namiki T, Terasawa K, Horie S . Dietary agonists of TRPV1 inhibit gastric acid secretion in mice. Planta Med. 2012; 78(17):1801-6. DOI: 10.1055/s-0032-1315387. View

12.

Xia R, Dekermendjian K, Lullau E, Dekker N . TRPV1: a therapy target that attracts the pharmaceutical interests. Adv Exp Med Biol. 2011; 704:637-65. DOI: 10.1007/978-94-007-0265-3_34. View

13.

Yoshimura M, Mikami T, Kuroda K, Nishida M, Ito K, Mondal A . Involvement of Transient Receptor Potential Vanilloid Receptor 1, (TRPV1)-Expressing Vagal Nerve in the Inhibitory Effect of Gastric Acidification on Exogenous Motilin-Induced Gastric Phase III Contractions in Suncus murinus. Dig Dis Sci. 2016; 61(6):1501-11. DOI: 10.1007/s10620-015-4023-z. View

14.

Pratter M . Cough and the common cold: ACCP evidence-based clinical practice guidelines. Chest. 2006; 129(1 Suppl):72S-74S. PMC: 7172553. DOI: 10.1378/chest.129.1_suppl.72S. View

15.

Bhave G, Gereau 4th R . Posttranslational mechanisms of peripheral sensitization. J Neurobiol. 2004; 61(1):88-106. DOI: 10.1002/neu.20083. View

16.

Toth A, Czikora A, Pasztor E, Dienes B, Bai P, Csernoch L . Vanilloid receptor-1 (TRPV1) expression and function in the vasculature of the rat. J Histochem Cytochem. 2013; 62(2):129-44. PMC: 3902097. DOI: 10.1369/0022155413513589. View

17.

Toth B, Benko S, Szollosi A, Kovacs L, Rajnavolgyi E, Biro T . Transient receptor potential vanilloid-1 signaling inhibits differentiation and activation of human dendritic cells. FEBS Lett. 2009; 583(10):1619-24. DOI: 10.1016/j.febslet.2009.04.031. View

18.

Hao J, Ju H, Zhao S, Junaid A, Dixon I . Elevation of expression of Smads 2, 3, and 4, decorin and TGF-beta in the chronic phase of myocardial infarct scar healing. J Mol Cell Cardiol. 1999; 31(3):667-78. DOI: 10.1006/jmcc.1998.0902. View

19.

DE Man J, Boeckx S, Anguille S, DE Winter B, De Schepper H, Herman A . Functional study on TRPV1-mediated signalling in the mouse small intestine: involvement of tachykinin receptors. Neurogastroenterol Motil. 2008; 20(5):546-56. DOI: 10.1111/j.1365-2982.2007.01064.x. View

20.

Niederau C, Grendell J . Intracellular vacuoles in experimental acute pancreatitis in rats and mice are an acidified compartment. J Clin Invest. 1988; 81(1):229-36. PMC: 442498. DOI: 10.1172/JCI113300. View