The Interaction of TRPV1 and Lipids: Insights into Lipid Metabolism

Overview

Journal Front Physiol

Date 2023 Jan 2

PMID 36589466

Authors

Shtaywy S Abdalla

Amani A Harb

Ihab M Almasri

Yasser K Bustanji

Affiliations

Soon will be listed here.

Abstract

Transient receptor potential vanilloid 1 (TRPV1), a non-selective ligand-gated cation channel with high permeability for Ca, has received considerable attention as potential therapeutic target for the treatment of several disorders including pain, inflammation, and hyperlipidemia. In particular, TRPV1 regulates lipid metabolism by mechanisms that are not completely understood. Interestingly, TRPV1 and lipids regulate each other in a reciprocal and complex manner. This review surveyed the recent literature dealing with the role of TRPV1 in the hyperlipidemia-associated metabolic syndrome. Besides TRPV1 structure, molecular mechanisms underlying the regulatory effect of TRPV1 on lipid metabolism such as the involvement of uncoupling proteins (UCPs), ATP-binding cassette (ABC) transporters, peroxisome proliferation-activated receptors (PPAR), sterol responsive element binding protein (SREBP), and hypoxia have been discussed. Additionally, this review extends our understanding of the lipid-dependent modulation of TRPV1 activity through affecting both the gating and the expression of TRPV1. The regulatory role of different classes of lipids such as phosphatidylinositol (PI), cholesterol, estrogen, and oleoylethanolamide (OEA), on TRPV1 has also been addressed.

Citing Articles

Capsaicin (But Not Other Vanillins) Enhances Estrogen Binding to Its Receptor: Implications for Power Sports and Cancers.

Pietrowicz M, Root-Bernstein R Life (Basel). 2025; 15(2).

PMID: 40003617 PMC: 11856108. DOI: 10.3390/life15020208.

ameliorates high-fat diet-induced obesity through modulating intestinal serotonin synthesis and lipid absorption in mice.

Wen X, Feng X, Xin F, An R, Huang H, Mao L Gut Microbes. 2024; 16(1):2423040.

PMID: 39569932 PMC: 11583587. DOI: 10.1080/19490976.2024.2423040.

A comprehensive review of capsaicin: Biosynthesis, industrial productions, processing to applications, and clinical uses.

Maharjan A, Vasamsetti B, Park J Heliyon. 2024; 10(21):e39721.

PMID: 39524861 PMC: 11543913. DOI: 10.1016/j.heliyon.2024.e39721.

Up-regulation of long non-coding RNA H19 ameliorates renal tubulointerstitial fibrosis by reducing lipid deposition and inflammatory response through regulation of the microRNA-130a-3p/long-chain acyl-CoA synthetase 1 axis.

Jiang Y, Ma F, Wang J, Chen X, Xue L, Chen X Noncoding RNA Res. 2024; 9(4):1120-1132.

PMID: 39022687 PMC: 11254502. DOI: 10.1016/j.ncrna.2024.05.002.

Association between Variants of the TRPV1 Gene and Body Composition in Sub-Saharan Africans.

Gianni M, Antinucci M, Bertoncini S, Taglioli L, Giuliani C, Luiselli D Genes (Basel). 2024; 15(6).

PMID: 38927688 PMC: 11202968. DOI: 10.3390/genes15060752.

References

Muller C, Lynch D, Hurst D, Reggio P . A Closer Look at Anandamide Interaction With TRPV1. Front Mol Biosci. 2020; 7:144. PMC: 7385410. DOI: 10.3389/fmolb.2020.00144. View

Manchanda M, Leishman E, Sangani K, Alamri A, Bradshaw H . Activation of TRPV1 by Capsaicin or Heat Drives Changes in 2-Acyl Glycerols and -Acyl Ethanolamines in a Time, Dose, and Temperature Dependent Manner. Front Cell Dev Biol. 2021; 9:611952. PMC: 8085603. DOI: 10.3389/fcell.2021.611952. View

Bessac B, Jordt S . Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology (Bethesda). 2008; 23:360-70. PMC: 2735846. DOI: 10.1152/physiol.00026.2008. View

Singh R, Bansal Y, Sodhi R, Singh D, Bishnoi M, Kondepudi K . Berberine attenuated olanzapine-induced metabolic alterations in mice: Targeting transient receptor potential vanilloid type 1 and 3 channels. Life Sci. 2020; 247:117442. DOI: 10.1016/j.lfs.2020.117442. View

Zhang K, Julius D, Cheng Y . Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell. 2021; 184(20):5138-5150.e12. PMC: 8488022. DOI: 10.1016/j.cell.2021.08.012. View

Luo Z, Ma L, Zhao Z, He H, Yang D, Feng X . TRPV1 activation improves exercise endurance and energy metabolism through PGC-1α upregulation in mice. Cell Res. 2011; 22(3):551-64. PMC: 3292293. DOI: 10.1038/cr.2011.205. View

Wei J, Lin J, Zhang J, Tang D, Xiang F, Cui L . TRPV1 activation mitigates hypoxic injury in mouse cardiomyocytes by inducing autophagy through the AMPK signaling pathway. Am J Physiol Cell Physiol. 2020; 318(5):C1018-C1029. DOI: 10.1152/ajpcell.00161.2019. View

Sanz-Salvador L, Andres-Borderia A, Ferrer-Montiel A, Planells-Cases R . Agonist- and Ca2+-dependent desensitization of TRPV1 channel targets the receptor to lysosomes for degradation. J Biol Chem. 2012; 287(23):19462-71. PMC: 3365984. DOI: 10.1074/jbc.M111.289751. View

Yazawa T, Inaoka Y, Okada R, Mizutani T, Yamazaki Y, Usami Y . PPAR-gamma coactivator-1alpha regulates progesterone production in ovarian granulosa cells with SF-1 and LRH-1. Mol Endocrinol. 2010; 24(3):485-96. PMC: 5419099. DOI: 10.1210/me.2009-0352. View

10.

Marshall N, Liang L, Bodkin J, Dessapt-Baradez C, Nandi M, Collot-Teixeira S . A role for TRPV1 in influencing the onset of cardiovascular disease in obesity. Hypertension. 2012; 61(1):246-52. DOI: 10.1161/HYPERTENSIONAHA.112.201434. View

11.

Chen C, Hsu L, Chen K, Chiu K, Chen C, Huang K . Emerging Roles of Calcium Signaling in the Development of Non-Alcoholic Fatty Liver Disease. Int J Mol Sci. 2022; 23(1). PMC: 8745268. DOI: 10.3390/ijms23010256. View

12.

Li Q, Li L, Wang F, Chen J, Zhao Y, Wang P . Dietary capsaicin prevents nonalcoholic fatty liver disease through transient receptor potential vanilloid 1-mediated peroxisome proliferator-activated receptor δ activation. Pflugers Arch. 2013; 465(9):1303-16. DOI: 10.1007/s00424-013-1274-4. View

13.

De Petrocellis L, Di Marzo V . Lipids as regulators of the activity of transient receptor potential type V1 (TRPV1) channels. Life Sci. 2005; 77(14):1651-66. DOI: 10.1016/j.lfs.2005.05.021. View

14.

Ye Z, Lu Y, Wu T . The impact of ATP-binding cassette transporters on metabolic diseases. Nutr Metab (Lond). 2020; 17:61. PMC: 7398066. DOI: 10.1186/s12986-020-00478-4. View

15.

Bratz I, Dick G, Tune J, Edwards J, Neeb Z, Dincer U . Impaired capsaicin-induced relaxation of coronary arteries in a porcine model of the metabolic syndrome. Am J Physiol Heart Circ Physiol. 2008; 294(6):H2489-96. DOI: 10.1152/ajpheart.01191.2007. View

16.

Vyklicky L, Novakova-Tousova K, Benedikt J, Samad A, Touska F, Vlachova V . Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin. Physiol Res. 2008; 57 Suppl 3:S59-S68. DOI: 10.33549/physiolres.931478. View

17.

Weidemann A, Johnson R . Biology of HIF-1alpha. Cell Death Differ. 2008; 15(4):621-7. DOI: 10.1038/cdd.2008.12. View

18.

Zhai K, Liskova A, Kubatka P, Busselberg D . Calcium Entry through TRPV1: A Potential Target for the Regulation of Proliferation and Apoptosis in Cancerous and Healthy Cells. Int J Mol Sci. 2020; 21(11). PMC: 7312732. DOI: 10.3390/ijms21114177. View

19.

Nakada-Tsukui K, Watanabe N, Maehama T, Nozaki T . Phosphatidylinositol Kinases and Phosphatases in . Front Cell Infect Microbiol. 2019; 9:150. PMC: 6563779. DOI: 10.3389/fcimb.2019.00150. View

20.

Krishnan V, Baskaran P, Thyagarajan B . Troglitazone activates TRPV1 and causes deacetylation of PPARγ in 3T3-L1 cells. Biochim Biophys Acta Mol Basis Dis. 2018; 1865(2):445-453. PMC: 6364553. DOI: 10.1016/j.bbadis.2018.11.004. View