TRPV1: The Key Bridge in Neuroimmune Interactions

Overview

Journal J Intensive Med

Specialty Critical Care

Date 2024 Sep 23

PMID 39310069

Authors

Jianwei Chen

Wenqian Sun

Youjia Zhu

Feng Zhao

Shuixiang Deng

Mi Tian

Yao Wang

Ye Gong

Affiliations

Soon will be listed here.

Abstract

The nervous and immune systems are crucial in fighting infections and inflammation and in maintaining immune homeostasis. The immune and nervous systems are independent, yet tightly integrated and coordinated organizations. Numerous molecules and receptors play key roles in enabling communication between the two systems. Transient receptor potential vanilloid subfamily member 1 (TRPV1) is a non-selective cation channel, recently shown to be widely expressed in the neuroimmune axis and implicated in neuropathic pain, autoimmune disorders, and immune cell function. TRPV1 is a key bridge in neuroimmune interactions, allowing for smooth and convenient communication between the two systems. Here, we discuss the coordinated cross-talking between the immune and nervous systems and the functional role and the functioning manner of the TRPV1 involved. We suggest that TRPV1 provides new insights into the collaborative relationship between the nervous and immune systems, highlighting exciting opportunities for advanced therapeutic approaches to treating neurogenic inflammation and immune-mediated diseases.

Citing Articles

Differential Effect of TRPV1 Modulators on Neural and Behavioral Responses to Taste Stimuli.

Rhyu M, Ozdener M, Lyall V Nutrients. 2024; 16(22).

PMID: 39599644 PMC: 11597080. DOI: 10.3390/nu16223858.

Unraveling TRPV1's Role in Cancer: Expression, Modulation, and Therapeutic Opportunities with Capsaicin.

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References

Foreman J, Jordan C, Oehme P, Renner H . Structure-activity relationships for some substance P-related peptides that cause wheal and flare reactions in human skin. J Physiol. 1983; 335:449-65. PMC: 1197362. DOI: 10.1113/jphysiol.1983.sp014543. View

Hwang S, Cho H, Kwak J, Lee S, Kang C, Jung J . Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. Proc Natl Acad Sci U S A. 2000; 97(11):6155-60. PMC: 18574. DOI: 10.1073/pnas.97.11.6155. View

Yuan J, Liu H, Zhang H, Wang T, Zheng Q, Li Z . Controlled Activation of TRPV1 Channels on Microglia to Boost Their Autophagy for Clearance of Alpha-Synuclein and Enhance Therapy of Parkinson's Disease. Adv Mater. 2022; 34(11):e2108435. DOI: 10.1002/adma.202108435. View

Iftinca M, Defaye M, Altier C . TRPV1-Targeted Drugs in Development for Human Pain Conditions. Drugs. 2020; 81(1):7-27. DOI: 10.1007/s40265-020-01429-2. View

Huang W, Yu F, Sanchez R, Liu Y, Min J, Hu J . TRPV1 promotes repetitive febrile seizures by pro-inflammatory cytokines in immature brain. Brain Behav Immun. 2015; 48:68-77. DOI: 10.1016/j.bbi.2015.01.017. View

Groneberg D, Niimi A, Dinh Q, Cosio B, Hew M, Fischer A . Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough. Am J Respir Crit Care Med. 2004; 170(12):1276-80. DOI: 10.1164/rccm.200402-174OC. View

Pavon-Romero G, Serrano-Perez N, Garcia-Sanchez L, Ramirez-Jimenez F, Teran L . Neuroimmune Pathophysiology in Asthma. Front Cell Dev Biol. 2021; 9:663535. PMC: 8155297. DOI: 10.3389/fcell.2021.663535. View

Yang F, Zheng J . Understand spiciness: mechanism of TRPV1 channel activation by capsaicin. Protein Cell. 2017; 8(3):169-177. PMC: 5326624. DOI: 10.1007/s13238-016-0353-7. View

Mezey E, Toth Z, Cortright D, Arzubi M, Krause J, Elde R . Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human. Proc Natl Acad Sci U S A. 2000; 97(7):3655-60. PMC: 16295. DOI: 10.1073/pnas.97.7.3655. View

10.

Li Y, Cai J, Han Y, Xiao X, Meng X, Su L . Enhanced function of TRPV1 via up-regulation by insulin-like growth factor-1 in a rat model of bone cancer pain. Eur J Pain. 2014; 18(6):774-84. DOI: 10.1002/j.1532-2149.2013.00420.x. View

11.

Miyake T, Shirakawa H, Nakagawa T, Kaneko S . Activation of mitochondrial transient receptor potential vanilloid 1 channel contributes to microglial migration. Glia. 2015; 63(10):1870-82. DOI: 10.1002/glia.22854. View

12.

Roosterman D, Goerge T, Schneider S, Bunnett N, Steinhoff M . Neuronal control of skin function: the skin as a neuroimmunoendocrine organ. Physiol Rev. 2006; 86(4):1309-79. DOI: 10.1152/physrev.00026.2005. View

13.

Kang S, Seo S, Bang S, Cho S, Choi K, Ryu Y . Inhibition of Spinal TRPV1 Reduces NMDA Receptor 2B Phosphorylation and Produces Anti-Nociceptive Effects in Mice with Inflammatory Pain. Int J Mol Sci. 2021; 22(20). PMC: 8539417. DOI: 10.3390/ijms222011177. View

14.

Zhang X, Li L, McNaughton P . Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150. Neuron. 2008; 59(3):450-61. DOI: 10.1016/j.neuron.2008.05.015. View

15.

Fernandes E, Brito C, Teixeira S, Barboza R, dos Reis A, Azevedo-Santos A . TRPV1 antagonism by capsazepine modulates innate immune response in mice infected with Plasmodium berghei ANKA. Mediators Inflamm. 2014; 2014:506450. PMC: 4158567. DOI: 10.1155/2014/506450. View

16.

Cevikbas F, Wang X, Akiyama T, Kempkes C, Savinko T, Antal A . A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1. J Allergy Clin Immunol. 2013; 133(2):448-60. PMC: 3960328. DOI: 10.1016/j.jaci.2013.10.048. View

17.

Nattkemper L, Tey H, Valdes-Rodriguez R, Lee H, Mollanazar N, Albornoz C . The Genetics of Chronic Itch: Gene Expression in the Skin of Patients with Atopic Dermatitis and Psoriasis with Severe Itch. J Invest Dermatol. 2018; 138(6):1311-1317. DOI: 10.1016/j.jid.2017.12.029. View

18.

McLeod I, He Y . Editorial: TRPV1: how thymocytes sense stress and respond with autophagy. J Leukoc Biol. 2012; 92(3):409-11. PMC: 3973986. DOI: 10.1189/jlb.0612269. View

19.

Storozhuk M, Moroz O, Zholos A . Multifunctional TRPV1 Ion Channels in Physiology and Pathology with Focus on the Brain, Vasculature, and Some Visceral Systems. Biomed Res Int. 2019; 2019:5806321. PMC: 6556840. DOI: 10.1155/2019/5806321. View

20.

Manzini S, Maggi C, Geppetti P, BACCIARELLI C . Capsaicin desensitization protects from antigen-induced bronchospasm in conscious guinea-pigs. Eur J Pharmacol. 1987; 138(2):307-8. DOI: 10.1016/0014-2999(87)90451-1. View