Rapamycin Protects Aging Muscle

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2019 Aug 28

PMID 31454792

Citations 15

Authors

Huibin Tang

Joseph B Shrager

Daniel Goldman

Affiliations

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Citing Articles

The mitochondrial-targeted peptide therapeutic elamipretide improves cardiac and skeletal muscle function during aging without detectable changes in tissue epigenetic or transcriptomic age.

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Challenging Sarcopenia: Exploring AdipoRon in Aging Skeletal Muscle as a Healthspan-Extending Shield.

Selvais C, Davis-Lopez de Carrizosa M, Versele R, Dubuisson N, Noel L, Brichard S Antioxidants (Basel). 2024; 13(9).

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Skeletal muscle dysfunction with advancing age.

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Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies.

Zheng Y, Feng J, Yu Y, Ling M, Wang X Arch Pharm Res. 2024; 47(4):301-324.

PMID: 38592582 DOI: 10.1007/s12272-024-01493-2.

Rapamycin protects mouse skin from ultraviolet B-induced photodamage by modulating Hspb2-mediated autophagy and apoptosis.

Li A, Chen A, Xu J, Wen Z, Bai G, Wang Z Mol Biol Rep. 2024; 51(1):80.

PMID: 38183537 DOI: 10.1007/s11033-023-08954-9.

References

Tang H, Inoki K, Brooks S, Okazawa H, Lee M, Wang J . mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism. Aging Cell. 2019; 18(3):e12943. PMC: 6516169. DOI: 10.1111/acel.12943. View

Walters H, Cox L . mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases. Int J Mol Sci. 2018; 19(8). PMC: 6121351. DOI: 10.3390/ijms19082325. View

Bodine S, Stitt T, Gonzalez M, Kline W, Stover G, Bauerlein R . Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol. 2001; 3(11):1014-9. DOI: 10.1038/ncb1101-1014. View

Saxton R, Sabatini D . mTOR Signaling in Growth, Metabolism, and Disease. Cell. 2017; 169(2):361-371. DOI: 10.1016/j.cell.2017.03.035. View

Castets P, Lin S, Rion N, Di Fulvio S, Romanino K, Guridi M . Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy. Cell Metab. 2013; 17(5):731-44. DOI: 10.1016/j.cmet.2013.03.015. View