The Emerging Role of the Sympathetic Nervous System in Skeletal Muscle Motor Innervation and Sarcopenia

Overview

Journal Ageing Res Rev

Specialty Geriatrics

Date 2021 Feb 21

PMID 33610815

Citations 29

Authors

Osvaldo Delbono

Anna Carolina Zaia Rodrigues

Henry Jacob Bonilla

Maria Laura Messi

Affiliations

Soon will be listed here.

Abstract

Examining neural etiologic factors'role in the decline of neuromuscular function with aging is essential to our understanding of the mechanisms underlying sarcopenia, the age-dependent decline in muscle mass, force and power. Innervation of the skeletal muscle by both motor and sympathetic axons has been established, igniting interest in determining how the sympathetic nervous system (SNS) affect skeletal muscle composition and function throughout the lifetime. Selective expression of the heart and neural crest derivative 2 gene in peripheral SNs increases muscle mass and force regulating skeletal muscle sympathetic and motor innervation; improving acetylcholine receptor stability and NMJ transmission; preventing inflammation and myofibrillar protein degradation; increasing autophagy; and probably enhancing protein synthesis. Elucidating the role of central SNs will help to define the coordinated response of the visceral and neuromuscular system to physiological and pathological challenges across ages. This review discusses the following questions: (1) Does the SNS regulate skeletal muscle motor innervation? (2) Does the SNS regulate presynaptic and postsynaptic neuromuscular junction (NMJ) structure and function? (3) Does sympathetic neuron (SN) regulation of NMJ transmission decline with aging? (4) Does maintenance of SNs attenuate aging sarcopenia? and (5) Do central SN group relays influence sympathetic and motor muscle innervation?

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References

Kamwa V, Welch C, Hassan-Smith Z . The endocrinology of sarcopenia and frailty. Minerva Endocrinol (Torino). 2020; 46(4):453-468. DOI: 10.23736/S2724-6507.20.03198-3. View

Hoeldtke R, Cilmi K . Effects of aging on catecholamine metabolism. J Clin Endocrinol Metab. 1985; 60(3):479-84. DOI: 10.1210/jcem-60-3-479. View

Zheng Z, Wang Z, Delbono O . Insulin-like growth factor-1 increases skeletal muscle dihydropyridine receptor alpha 1S transcriptional activity by acting on the cAMP-response element-binding protein element of the promoter region. J Biol Chem. 2002; 277(52):50535-42. DOI: 10.1074/jbc.M210526200. View

Jessen K, Mirsky R . The repair Schwann cell and its function in regenerating nerves. J Physiol. 2016; 594(13):3521-31. PMC: 4929314. DOI: 10.1113/JP270874. View

Orimo S, Kanazawa T, Nakamura A, Uchihara T, Mori F, Kakita A . Degeneration of cardiac sympathetic nerve can occur in multiple system atrophy. Acta Neuropathol. 2006; 113(1):81-6. DOI: 10.1007/s00401-006-0160-y. View

Bezakova G, Lomo T . Muscle activity and muscle agrin regulate the organization of cytoskeletal proteins and attached acetylcholine receptor (AchR) aggregates in skeletal muscle fibers. J Cell Biol. 2001; 153(7):1453-63. PMC: 2150728. DOI: 10.1083/jcb.153.7.1453. View

Carter M, Yizhar O, Chikahisa S, Nguyen H, Adamantidis A, Nishino S . Tuning arousal with optogenetic modulation of locus coeruleus neurons. Nat Neurosci. 2010; 13(12):1526-33. PMC: 3174240. DOI: 10.1038/nn.2682. View

Silveira W, Goncalves D, Graca F, Andrade-Lopes A, Bergantin L, Zanon N . Activating cAMP/PKA signaling in skeletal muscle suppresses the ubiquitin-proteasome-dependent proteolysis: implications for sympathetic regulation. J Appl Physiol (1985). 2014; 117(1):11-9. DOI: 10.1152/japplphysiol.01055.2013. View

Johnson H, Mossberg K, Arvidsson U, Piehl F, Hokfelt T, Ulfhake B . Increase in alpha-CGRP and GAP-43 in aged motoneurons: a study of peptides, growth factors, and ChAT mRNA in the lumbar spinal cord of senescent rats with symptoms of hindlimb incapacities. J Comp Neurol. 1995; 359(1):69-89. DOI: 10.1002/cne.903590106. View

10.

Landi F, Marzetti E, Martone A, Bernabei R, Onder G . Exercise as a remedy for sarcopenia. Curr Opin Clin Nutr Metab Care. 2013; 17(1):25-31. DOI: 10.1097/MCO.0000000000000018. View

11.

Ohara O, Gahara Y, Miyake T, Teraoka H, Kitamura T . Neurofilament deficiency in quail caused by nonsense mutation in neurofilament-L gene. J Cell Biol. 1993; 121(2):387-95. PMC: 2200107. DOI: 10.1083/jcb.121.2.387. View

12.

Rychlik J, Hsieh M, Eiden L, Lewis E . Phox2 and dHAND transcription factors select shared and unique target genes in the noradrenergic cell type. J Mol Neurosci. 2005; 27(3):281-92. DOI: 10.1385/JMN:27:3:281. View

13.

Femminella G, Rengo G, Komici K, Iacotucci P, Petraglia L, Pagano G . Autonomic dysfunction in Alzheimer's disease: tools for assessment and review of the literature. J Alzheimers Dis. 2014; 42(2):369-77. DOI: 10.3233/JAD-140513. View

14.

Xiang H, Liu C, Liu T, Xiong J . Central circuits regulating the sympathetic outflow to lumbar muscles in spinally transected mice by retrograde transsynaptic transport. Int J Clin Exp Pathol. 2014; 7(6):2987-97. PMC: 4097212. View

15.

Thoma A, Lightfoot A . NF-kB and Inflammatory Cytokine Signalling: Role in Skeletal Muscle Atrophy. Adv Exp Med Biol. 2018; 1088:267-279. DOI: 10.1007/978-981-13-1435-3_12. View

16.

Srikanthan P, Hevener A, Karlamangla A . Sarcopenia exacerbates obesity-associated insulin resistance and dysglycemia: findings from the National Health and Nutrition Examination Survey III. PLoS One. 2012; 5(5):e10805. PMC: 3279294. DOI: 10.1371/journal.pone.0010805. View

17.

Le Panse B, Arlettaz A, Portier H, Lecoq A, de Ceaurriz J, Collomp K . Effects of acute salbutamol intake during supramaximal exercise in women. Br J Sports Med. 2007; 41(7):430-4. PMC: 2465367. DOI: 10.1136/bjsm.2006.033845. View

18.

Furlow J, Watson M, Waddell D, Neff E, Baehr L, Ross A . Altered gene expression patterns in muscle ring finger 1 null mice during denervation- and dexamethasone-induced muscle atrophy. Physiol Genomics. 2013; 45(23):1168-85. PMC: 3882710. DOI: 10.1152/physiolgenomics.00022.2013. View

19.

Laplante M, Sabatini D . mTOR signaling in growth control and disease. Cell. 2012; 149(2):274-93. PMC: 3331679. DOI: 10.1016/j.cell.2012.03.017. View

20.

Fry C, Lee J, Mula J, Kirby T, Jackson J, Liu F . Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia. Nat Med. 2014; 21(1):76-80. PMC: 4289085. DOI: 10.1038/nm.3710. View