Risk of Adverse Perinatal Outcomes After Oocyte Donation: a Systematic Review and Meta-analysis

Overview

Journal J Assist Reprod Genet

Publisher Springer

Specialties Genetics
Reproductive Medicine

Date 2019 Aug 24

PMID 31440959

Citations 19

Authors

Jose Moreno-Sepulveda

Miguel A Checa

Affiliations

Soon will be listed here.

Abstract

Research Question: In women with singleton pregnancies conceived after assisted reproductive technologies, does the in vitro fertilization with oocyte donation (IVF-OD) affect the perinatal and maternal outcomes compared to autologous in vitro fertilization (IVF-AO)?

Design: Systematic review and meta-analysis of studies comparing perinatal and maternal outcomes in singleton pregnancies resulting from IVF-OD versus IVF-AO. An electronic literature search in Pubmed, MEDLINE, and Cochrane database was performed. The main outcome measures were hypertensive disorders in pregnancy, preeclampsia, severe preeclampsia, pregnancy-induced hypertension, preterm birth, early preterm birth, low birth weight, and very low birth weight.

Results: Twenty-three studies were included. IVF-OD is associated with a higher risk of hypertensive disorders in pregnancy (OR 2.63, 2.17-3.18), preeclampsia (OR 2.64; 2.29-3.04), severe preeclampsia (OR 3.22; 2.30-4.49), pregnancy-induced hypertension (OR 2.16; 1.79-2.62), preterm birth (OR 1.57; 1.33-1.86), early preterm birth (OR 1.80; 1.51-2.15), low birth weight (OR 1.25, 1.20-1.30), very low birth weight (OR 1.37, 1.22-1.54), gestational diabetes (OR 1.27; 1.03-1.56), and cesarean section (OR 2.28; 2.14-2.42). There was no significant difference in the risk of preterm birth or low birth weight when adjusted for preeclampsia.

Conclusions: IVF-OD patients should be considered an independent risk factor for some adverse perinatal outcomes, mainly hypertensive disorders in pregnancy, preeclampsia, and severe preeclampsia. Immunological and hormonal aspects may be involved in these results, and further research focusing in the etiopathogenesis of these pathologies are needed.

Citing Articles

High-Risk Outcomes in In Vitro Fertilization Pregnancies for Women of a Very Advanced Maternal Age: Insights from a Multi-Hospital Study in Greece.

Loukopoulos T, Zikopoulos A, Kolibianakis E, Vatopoulou A, Gkrozou F, Sotiriou S J Clin Med. 2025; 14(4).

PMID: 40004853 PMC: 11855963. DOI: 10.3390/jcm14041323.

Sirtuins and Their Implications in the Physiopathology of Gestational Diabetes Mellitus.

Zgutka K, Tkacz M, Grabowska M, Mikolajek-Bedner W, Tarnowski M Pharmaceuticals (Basel). 2025; 18(1).

PMID: 39861104 PMC: 11768332. DOI: 10.3390/ph18010041.

[Obstetric and neonatal outcomes in pregnancies conceived by assisted reproductive technology in an Argentine cohort].

Diez Brito M, Sevillano G, Negri F, Mongelos M, Izbizky G Rev Fac Cien Med Univ Nac Cordoba. 2024; 81(4):734-751.

PMID: 39670905 PMC: 11905777. DOI: 10.31053/1853.0605.v81.n4.44425.

Stringent Regulations of Oocyte Donation Among Jewish Women in Israel: Characteristics and Outcomes of the National Oocyte Donation Program in One Central IVF Unit.

Preisler L, Samara N, Kalma Y, Arad T, Groutz A, Azem F J Relig Health. 2024; 64(1):124-147.

PMID: 39652246 PMC: 11845420. DOI: 10.1007/s10943-024-02200-7.

Perinatal Outcomes of Singleton, Twin and Triplet Gestations after Oocyte Donation: A Retrospective, Population-Based Cohort Analysis.

Eliner O, Koren R, Ram H, Levi M, Herzberger E, Wiser A Children (Basel). 2024; 11(8).

PMID: 39201897 PMC: 11353069. DOI: 10.3390/children11080962.

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