Sirtuins and Their Implications in the Physiopathology of Gestational Diabetes Mellitus

Overview

Journal Pharmaceuticals (Basel)

Publisher MDPI

Date 2025 Jan 25

PMID 39861104

Authors

Katarzyna Zgutka

Marta Tkacz

Marta Grabowska

Wioletta Mikolajek-Bedner

Maciej Tarnowski

Affiliations

Soon will be listed here.

Abstract

Gestational diabetes mellitus (GDM) imposes serious short- and long-term health problems for the mother and her child. An effective therapeutic that can reduce the incidence of GDM and improve long-term outcomes is a major research priority and is very important for public health. Unfortunately, despite numerous studies, the molecular mechanisms underlying GDM are not fully defined and require further study. Chronic low-grade inflammation, oxidative stress, and insulin resistance are central features of pregnancies complicated by GDM. There is evidence of the involvement of sirtuins, which are NAD+-dependent histone deacetylases, in energy metabolism and inflammation. Taking these facts into consideration, the role of sirtuins in the pathomechanism of GDM will be discussed.

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