An FMRI-study on Single-sided Deafness: Spectral-temporal Properties and Side of Stimulation Modulates Hemispheric Dominance

Overview

Journal Neuroimage Clin

Publisher Elsevier

Specialties Neurology
Radiology

Date 2019 Aug 17

PMID 31419767

Citations 6

Authors

Peder O Laugen Heggdal

Hans Jorgen Aarstad

Jonas Brannstrom

Flemming S Vassbotn

Karsten Specht

Affiliations

Soon will be listed here.

Abstract

Objective: Our main aim was to investigate the blood oxygenation level dependent (BOLD) response to monaural and binaural speech- and non-speech stimuli as measured with fMRI in subjects with single-sided deafness and in normal hearing controls. We hypothesised that the response to monaural stimulation in both normal hearing subjects and persons with single-sided deafness would vary with the complexity and nature of the stimuli and the side of stimulation.

Design: Patients with left- and right single-sided deafness and controls with normal hearing receiving either binaural or monaural stimuli were tested using speech and non-speech auditory stimuli in an event-related fMRI experiment.

Study Sample: Twenty-two patients with single-sided deafness after treatment for vestibular schwannoma and 50 normal hearing controls.

Results: Normal hearing persons receiving right side monaural stimuli activate bilateral temporal regions. Activation following left side monaural stimulation is more right lateralized. Persons with single-sided deafness respond similarly to controls to monaural stimulation. Persons with right side single-sided deafness show activation of frontal cortical regions not seen in persons with left side single-sided deafness following speech stimuli. This is possibly related to increased effort and more frequently reported problems with communication. Right side single-sided deafness is related to increased activation of areas usually related to processing of degraded input, including the thalamus.

Conclusion: Hemispheric dominance following monaural auditory stimulation is modulated by the spectral-temporal properties of the stimuli and by which ear is stimulated. Differences between patients with right- and left side deafness suggests that right side deafness is related to increased activation of areas involved in processing of degraded input.

Citing Articles

Cortical mechanisms of across-ear speech integration investigated using functional near-infrared spectroscopy (fNIRS).

Sobczak G, Zhou X, Moore L, Bolt D, Litovsky R PLoS One. 2024; 19(9):e0307158.

PMID: 39292701 PMC: 11410267. DOI: 10.1371/journal.pone.0307158.

The effect of noise on the cortical activity patterns of speech processing in adults with single-sided deafness.

Han J, Lee J, Lee H Front Neurol. 2023; 14:1054105.

PMID: 37006498 PMC: 10060629. DOI: 10.3389/fneur.2023.1054105.

Altered topological properties of the intrinsic functional brain network in patients with right-sided unilateral hearing loss caused by acoustic neuroma.

Fan Z, Fan Z, Qiu T, Hu L, Shi Y, Xia Y Brain Imaging Behav. 2022; 16(4):1873-1883.

PMID: 35397062 DOI: 10.1007/s11682-022-00658-1.

Proficiency in Using Level Cue for Sound Localization Is Related to the Auditory Cortical Structure in Patients With Single-Sided Deafness.

Hee Kim J, Shim L, Bahng J, Lee H Front Neurosci. 2021; 15:749824.

PMID: 34707477 PMC: 8542703. DOI: 10.3389/fnins.2021.749824.

Understanding degraded speech leads to perceptual gating of a brainstem reflex in human listeners.

Hernandez-Perez H, Mikiel-Hunter J, McAlpine D, Dhar S, Boothalingam S, Monaghan J PLoS Biol. 2021; 19(10):e3001439.

PMID: 34669696 PMC: 8559948. DOI: 10.1371/journal.pbio.3001439.

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