Gene Polymorphisms and Neuroblastoma Susceptibility in Chinese Children

Overview

Journal J Cancer

Specialty Oncology

Date 2019 Aug 16

PMID 31413734

Citations 4

Authors

Jiwen Cheng

Zhenjian Zhuo

Pu Zhao

Jinhong Zhu

Yijuan Xin

Jiao Zhang

Peng Li

Ya Gao

Jing He

Baijun Zheng

Affiliations

Soon will be listed here.

Abstract

Neuroblastoma is a heterogeneous cancer frequently occurring in childhood. Germline mutations of oncogene are implicated in several types of cancer. However, whether common single nucleotide polymorphisms (SNPs) in gene are associated with neuroblastoma risk has received relatively few attentions. In this multi-center study, we aimed to elucidate the contributing role of SNPs in neuroblastoma risk. We successfully genotyped three potentially functional SNPs (rs1136410 A>G, rs2666428 T>C, rs8679 A>G) in 469 neuroblastoma cases and 998 controls. We did not detect any significant association between the analyzed SNPs and neuroblastoma risk in single SNP analysis. However, stratified analysis revealed that rs1136410 AG/GG carriers were more likely to develop tumors arising from mediastinum (AG/GG vs. AA: adjusted OR=1.65, 95% CI=1.06-2.56, =0.028). Moreover, rs2666428 TC/CC carriers were at significantly lower risk to develop tumors from "other sites" (TC/CC vs. TT: adjusted OR=0.44, 95% CI=0.20-0.96, =0.040). Our findings failed to provide evidence of the conferring role of the gene polymorphisms in the risk of neuroblastoma. Further investigations of the association between gene SNPs and neuroblastoma risk are warranted.

Citing Articles

rs1136410 Val762Ala contributes to an increased risk of overall cancer in the East Asian population: a meta-analysis.

Xin Y, Yang L, Su M, Cheng X, Zhu L, Liu J J Int Med Res. 2021; 49(3):300060521992956.

PMID: 33706586 PMC: 8168028. DOI: 10.1177/0300060521992956.

PARP1 rs1136410 C/C genotype associated with an increased risk of esophageal cancer in smokers.

Zhou R, Li Y, Wang N, Niu C, Huang X, Cao S Mol Biol Rep. 2021; 48(2):1485-1491.

PMID: 33528729 DOI: 10.1007/s11033-021-06169-4.

PARP1 Gene Polymorphisms and the Prognosis of Esophageal Cancer Patients from Cixian High-Incidence Region in Northern China.

Zhou R, Li Y, Wang N, Niu C, Huang X, Cao S Asian Pac J Cancer Prev. 2020; 21(10):2987-2992.

PMID: 33112558 PMC: 7798169. DOI: 10.31557/APJCP.2020.21.10.2987.

Association of PARP1 polymorphisms with response to chemotherapy in patients with high-risk neuroblastoma.

Avitabile M, Lasorsa V, Cantalupo S, Cardinale A, Cimmino F, Montella A J Cell Mol Med. 2020; 24(7):4072-4081.

PMID: 32103589 PMC: 7171401. DOI: 10.1111/jcmm.15058.

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