PARP Inhibition: PARP1 and Beyond

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2010 Mar 5

PMID 20200537

Citations 683

Authors

Michele Rouleau

Anand Patel

Michael J Hendzel

Scott H Kaufmann

Guy G Poirier

Affiliations

Soon will be listed here.

Abstract

Recent findings have thrust poly(ADP-ribose) polymerases (PARPs) into the limelight as potential chemotherapeutic targets. To provide a framework for understanding these recent observations, we review what is known about the structures and functions of the family of PARP enzymes, and then outline a series of questions that should be addressed to guide the rational development of PARP inhibitors as anticancer agents.

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