Rs1136410 Val762Ala Contributes to an Increased Risk of Overall Cancer in the East Asian Population: a Meta-analysis

Overview

Journal J Int Med Res

Publisher Sage Publications

Specialty General Medicine

Date 2021 Mar 12

PMID 33706586

Citations 2

Authors

Yijuan Xin

Liu Yang

Mingquan Su

Xiaoli Cheng

Lin Zhu

Jiayun Liu

Affiliations

Soon will be listed here.

Abstract

Objectives: To investigate the association between poly(ADP-ribose) polymerase 1 () rs1136410 Val762Ala and cancer risk in Asian populations, as published findings remain controversial.

Methods: The PubMed and EMBASE databases were searched, and references of identified studies and reviews were screened, to find relevant studies. Meta-analyses were performed to evaluate the association between rs1136410 Val762Ala and cancer risk, reported as odds ratio (OR) and 95% confidence interval (CI).

Results: A total of 24 studies with 8 926 cases and 15 295 controls were included. Overall, a significant association was found between rs1136410 Val762Ala and cancer risk in East Asians (homozygous: OR 1.19, 95% CI 1.06, 1.35; heterozygous: OR 1.10, 95% CI 1.04, 1.17; recessive: OR 1.13, 95% CI 1.02, 1.25; dominant: OR 1.13, 95% CI 1.06, 1.19; and allele comparison: OR 1.09, 95% CI 1.03, 1.15). Stratification analyses by race and cancer type revealed similar results for gastric cancer among the Chinese population.

Conclusion: The findings suggest that rs1136410 Val762Ala may be significantly associated with an increased cancer risk in Asians, particularly the Chinese population.

Citing Articles

Computational compensatory mutation discovery approach: Predicting a PARP1 variant rescue mutation.

Ravishankar K, Jiang X, Leddin E, Morcos F, Cisneros G Biophys J. 2022; 121(19):3663-3673.

PMID: 35642254 PMC: 9617126. DOI: 10.1016/j.bpj.2022.05.036.

Environmental Tobacco Smoke in Occupational Settings: Effect and Susceptibility Biomarkers in Workers From Lisbon Restaurants and Bars.

Vital N, Antunes S, Louro H, Vaz F, Simoes T, Penque D Front Public Health. 2021; 9:674142.

PMID: 34150711 PMC: 8213454. DOI: 10.3389/fpubh.2021.674142.

References

Lindahl T, Wood R . Quality control by DNA repair. Science. 1999; 286(5446):1897-905. DOI: 10.1126/science.286.5446.1897. View

Yuan H, Li H, Ma H, Niu Y, Wu Y, Zhang S . Genetic polymorphisms in key DNA repair genes and risk of head and neck cancer in a Chinese population. Exp Ther Med. 2012; 3(4):719-724. PMC: 3438586. DOI: 10.3892/etm.2012.476. View

Yu P, Liu Y, Zhang J, Qu X, Jin B, Zhang Y . Correlation between PARP-1 Val762Ala polymorphism and the risk of lung cancer in a Chinese population. Tumour Biol. 2014; 36(1):177-81. DOI: 10.1007/s13277-014-2373-3. View

Wang X, Ma K, Zhao Y, Wang G, Li W . XRCC1 rs25487 polymorphism is associated with lung cancer risk in epidemiologically susceptible Chinese people. Genet Mol Res. 2015; 14(4):15530-8. DOI: 10.4238/2015.December.1.3. View

Zhang Z, Miao X, Tan W, Guo Y, Zhang X, Lin D . [Correlation of genetic polymorphisms in DNA repair genes ADPRT and XRCC1 to risk of gastric cancer]. Ai Zheng. 2006; 25(1):7-10. View

Zhang X, Miao X, Liang G, Hao B, Wang Y, Tan W . Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer. Cancer Res. 2005; 65(3):722-6. View

Tong W, Yang Y, Cao W, Galendo D, Frappart L, Shen Y . Poly(ADP-ribose) polymerase-1 plays a role in suppressing mammary tumourigenesis in mice. Oncogene. 2006; 26(26):3857-67. DOI: 10.1038/sj.onc.1210156. View

Zhang L, Ruan Z, Hong Q, Gong X, Hu Z, Huang Y . Single nucleotide polymorphisms in DNA repair genes and risk of cervical cancer: A case-control study. Oncol Lett. 2012; 3(2):351-362. PMC: 3362506. DOI: 10.3892/ol.2011.463. View

Mantel N, Haenszel W . Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959; 22(4):719-48. View

10.

Hao B, Wang H, Zhou K, Li Y, Chen X, Zhou G . Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma. Cancer Res. 2004; 64(12):4378-84. DOI: 10.1158/0008-5472.CAN-04-0372. View

11.

DerSimonian R, Laird N . Meta-analysis in clinical trials. Control Clin Trials. 1986; 7(3):177-88. DOI: 10.1016/0197-2456(86)90046-2. View

12.

Zhai X, Liu J, Hu Z, Wang S, Qing J, Wang X . Polymorphisms of ADPRT Val762Ala and XRCC1 Arg399Glu and risk of breast cancer in Chinese women: a case control analysis. Oncol Rep. 2005; 15(1):247-52. View

13.

Nakao M, Hosono S, Ito H, Watanabe M, Mizuno N, Sato S . Selected polymorphisms of base excision repair genes and pancreatic cancer risk in Japanese. J Epidemiol. 2012; 22(6):477-83. PMC: 3798558. DOI: 10.2188/jea.JE20120010. View

14.

Schreiber V, Dantzer F, Ame J, de Murcia G . Poly(ADP-ribose): novel functions for an old molecule. Nat Rev Mol Cell Biol. 2006; 7(7):517-28. DOI: 10.1038/nrm1963. View

15.

Masutani M, Nakagama H, Sugimura T . Poly(ADP-ribose) and carcinogenesis. Genes Chromosomes Cancer. 2003; 38(4):339-48. DOI: 10.1002/gcc.10250. View

16.

Shi Y, Xu W, Zhang X . Association of the hOGG1 Ser326Cys polymorphism with gynecologic cancer susceptibility: a meta-analysis. Biosci Rep. 2020; 40(12). PMC: 7693197. DOI: 10.1042/BSR20203245. View

17.

Jin X, Kim H, Lee I, Park K, Kim H, Choi J . PARP-1 Val762Ala polymorphism is associated with reduced risk of non-Hodgkin lymphoma in Korean males. BMC Med Genet. 2010; 11:38. PMC: 2843603. DOI: 10.1186/1471-2350-11-38. View

18.

Wang M, Qin C, Zhu J, Yuan L, Fu G, Zhang Z . Genetic variants of XRCC1, APE1, and ADPRT genes and risk of bladder cancer. DNA Cell Biol. 2010; 29(6):303-11. DOI: 10.1089/dna.2009.0969. View

19.

Heinen C, Schmutte C, Fishel R . DNA repair and tumorigenesis: lessons from hereditary cancer syndromes. Cancer Biol Ther. 2002; 1(5):477-85. DOI: 10.4161/cbt.1.5.160. View

20.

Wood R, Mitchell M, Sgouros J, Lindahl T . Human DNA repair genes. Science. 2001; 291(5507):1284-9. DOI: 10.1126/science.1056154. View