Calcium Phosphate Coated 3D Printed Porous Titanium with Nanoscale Surface Modification for Orthopedic and Dental Applications

Overview

Journal Mater Des

Date 2019 Aug 14

PMID 31406392

Citations 24

Authors

Susmita Bose

Dishary Banerjee

Anish Shivaram

Solaiman Tarafder

Amit Bandyopadhyay

Affiliations

Soon will be listed here.

Abstract

This study aims to improve the interfacial bonding between the osseous host tissue and the implant surface through the application of doped calcium phosphate (CaP) coating on 3D printed porous titanium. Porous titanium (Ti) cylinders with 25% volume porosity were fabricated using Laser Engineered Net Shaping (LENS™), a commercial 3D Printing technique. The surface of these 3D printed cylinders was modified by growing TiO nanotubes first, followed by a coating of with Sr and Si doped bioactive CaP ceramic in simulated body fluid (SBF). Doped CaP coated implants were hypothesized to show enhanced early stage bone tissue integration. Biological properties of these implants were investigated using a rat distal femur model after 4 and 10 weeks. CaP coated porous Ti implants have enhanced tissue ingrowth as was evident from the CT scan analysis, push out test results, and the histological analysis compared to porous implants with or without surface modification via titania nanotubes. Increased osteoid-like new bone formation and accelerated mineralization was revealed inside the CaP coated porous implants. It is envisioned that such an approach of adding a bioactive doped CaP layer on porous Ti surface can reduce healing time by enhancing early stage osseointegration .

Citing Articles

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3D Printing and Surface Engineering of Ti6Al4V Scaffolds for Enhanced Osseointegration in an In Vitro Study.

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References

Guyer R, Abitbol J, Ohnmeiss D, Yao C . Evaluating Osseointegration Into a Deeply Porous Titanium Scaffold: A Biomechanical Comparison With PEEK and Allograft. Spine (Phila Pa 1976). 2016; 41(19):E1146-E1150. DOI: 10.1097/BRS.0000000000001672. View

Goodman S, Yao Z, Keeney M, Yang F . The future of biologic coatings for orthopaedic implants. Biomaterials. 2013; 34(13):3174-83. PMC: 3582840. DOI: 10.1016/j.biomaterials.2013.01.074. View

Karageorgiou V, Kaplan D . Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials. 2005; 26(27):5474-91. DOI: 10.1016/j.biomaterials.2005.02.002. View

Liu W, Su P, Chen S, Wang N, Ma Y, Liu Y . Synthesis of TiO2 nanotubes with ZnO nanoparticles to achieve antibacterial properties and stem cell compatibility. Nanoscale. 2014; 6(15):9050-62. DOI: 10.1039/c4nr01531b. View

Fielding G, Roy M, Bandyopadhyay A, Bose S . Antibacterial and biological characteristics of silver containing and strontium doped plasma sprayed hydroxyapatite coatings. Acta Biomater. 2012; 8(8):3144-52. PMC: 3393112. DOI: 10.1016/j.actbio.2012.04.004. View

Su E, Justin D, Pratt C, Sarin V, Nguyen V, Oh S . Effects of titanium nanotubes on the osseointegration, cell differentiation, mineralisation and antibacterial properties of orthopaedic implant surfaces. Bone Joint J. 2018; 100-B(1 Supple A):9-16. PMC: 6424438. DOI: 10.1302/0301-620X.100B1.BJJ-2017-0551.R1. View

Clemow A, Weinstein A, Klawitter J, Koeneman J, Anderson J . Interface mechanics of porous titanium implants. J Biomed Mater Res. 1981; 15(1):73-82. DOI: 10.1002/jbm.820150111. View

Raphel J, Holodniy M, Goodman S, Heilshorn S . Multifunctional coatings to simultaneously promote osseointegration and prevent infection of orthopaedic implants. Biomaterials. 2016; 84:301-314. PMC: 4883578. DOI: 10.1016/j.biomaterials.2016.01.016. View

Bonnelye E, Chabadel A, Saltel F, Jurdic P . Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro. Bone. 2007; 42(1):129-38. DOI: 10.1016/j.bone.2007.08.043. View

10.

Bandyopadhyay A, Shivaram A, Tarafder S, Sahasrabudhe H, Banerjee D, Bose S . In Vivo Response of Laser Processed Porous Titanium Implants for Load-Bearing Implants. Ann Biomed Eng. 2016; 45(1):249-260. PMC: 5159332. DOI: 10.1007/s10439-016-1673-8. View

11.

Brammer K, Oh S, Cobb C, Bjursten L, van der Heyde H, Jin S . Improved bone-forming functionality on diameter-controlled TiO(2) nanotube surface. Acta Biomater. 2009; 5(8):3215-23. DOI: 10.1016/j.actbio.2009.05.008. View

12.

Taniguchi N, Fujibayashi S, Takemoto M, Sasaki K, Otsuki B, Nakamura T . Effect of pore size on bone ingrowth into porous titanium implants fabricated by additive manufacturing: An in vivo experiment. Mater Sci Eng C Mater Biol Appl. 2015; 59:690-701. DOI: 10.1016/j.msec.2015.10.069. View

13.

Bose S, Ke D, Sahasrabudhe H, Bandyopadhyay A . Additive manufacturing of biomaterials. Prog Mater Sci. 2019; 93:45-111. PMC: 6690629. DOI: 10.1016/j.pmatsci.2017.08.003. View

14.

Mercado C, Seeley Z, Bandyopadhyay A, Bose S, McHale J . Photoluminescence of dense nanocrystalline titanium dioxide thin films: effect of doping and thickness and relation to gas sensing. ACS Appl Mater Interfaces. 2011; 3(7):2281-8. DOI: 10.1021/am2006433. View

15.

Pabbruwe M, Standard O, Sorrell C, Howlett C . Bone formation within alumina tubes: effect of calcium, manganese, and chromium dopants. Biomaterials. 2004; 25(20):4901-10. DOI: 10.1016/j.biomaterials.2004.01.005. View

16.

Kokubo T, Takadama H . How useful is SBF in predicting in vivo bone bioactivity?. Biomaterials. 2006; 27(15):2907-15. DOI: 10.1016/j.biomaterials.2006.01.017. View

17.

Ke D, Robertson S, Dernell W, Bandyopadhyay A, Bose S . Effects of MgO and SiO on Plasma-Sprayed Hydroxyapatite Coating: An in Vivo Study in Rat Distal Femoral Defects. ACS Appl Mater Interfaces. 2017; 9(31):25731-25737. DOI: 10.1021/acsami.7b05574. View

18.

Maggi A, Li H, Greer J . Three-dimensional nano-architected scaffolds with tunable stiffness for efficient bone tissue growth. Acta Biomater. 2017; 63:294-305. PMC: 5663471. DOI: 10.1016/j.actbio.2017.09.007. View

19.

Thieme M, Wieters K, Bergner F, Scharnweber D, Worch H, Ndop J . Titanium powder sintering for preparation of a porous functionally graded material destined for orthopaedic implants. J Mater Sci Mater Med. 2004; 12(3):225-31. DOI: 10.1023/a:1008958914818. View

20.

Friberg B, Jemt T, Lekholm U . Early failures in 4,641 consecutively placed Brånemark dental implants: a study from stage 1 surgery to the connection of completed prostheses. Int J Oral Maxillofac Implants. 1991; 6(2):142-6. View