Unsalted Tomato Juice Intake Improves Blood Pressure and Serum Low-density Lipoprotein Cholesterol Level in Local Japanese Residents at Risk of Cardiovascular Disease

Overview

Journal Food Sci Nutr

Specialty Biotechnology

Date 2019 Aug 2

PMID 31367355

Citations 3

Authors

Tamami Odai

Masakazu Terauchi

Daisaku Okamoto

Asuka Hirose

Naoyuki Miyasaka

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to investigate the effects of unsalted tomato juice intake on cardiovascular risk markers in local Japanese residents. Four hundred and eighty-one local residents in Kuriyama, Japan, were enrolled in this study. Throughout the year of the study, they were provided with as much unsalted tomato juice as they wanted. Participants were screened for cardiovascular risk markers, such as blood pressure (BP), serum lipid profile, and glucose tolerance, before and after the study period. Of the study participants, 260 participated in a detailed study of their lifestyle factors. The average ages of the 184 male and 297 female participants were 56.3 ± 13.3 (mean ± ) and 58.4 ± 11.7 years, respectively. BP in 94 participants with untreated prehypertension or hypertension was significantly lowered (systolic BP, 141.2 ± 12.1-137.0 ± 16.3 mmHg, = 0.003; diastolic BP, 83.3 ± 10.1-80.9 ± 11.1 mmHg, = 0.012, paired test). Further, the serum low-density lipoprotein cholesterol (LDL-C) level in 125 participants with untreated dyslipidemia significantly decreased (155.0 ± 23.2-149.9 ± 25.0 mg/dl, = 0.005, paired test). These beneficial effects were not different between sexes and among the different age groups. No significant difference in lifestyle was found before and after the study. Unsalted tomato juice intake improved systolic and diastolic BP and serum LDL-C level in local Japanese residents at risk of cardiovascular conditions.

Citing Articles

The Effect of Thermal Processes on the Organoleptic and Nutraceutical Quality of Tomato Fruit ( L.).

Narra F, Brigante F, Piragine E, Solovyev P, Benedetti G, Araniti F Foods. 2024; 13(22).

PMID: 39594094 PMC: 11593577. DOI: 10.3390/foods13223678.

Impact of thermal processing on polyphenols, carotenoids, glucosinolates, and ascorbic acid in fruit and vegetables and their cardiovascular benefits.

Narra F, Piragine E, Benedetti G, Ceccanti C, Florio M, Spezzini J Compr Rev Food Sci Food Saf. 2024; 23(6):e13426.

PMID: 39169551 PMC: 11605278. DOI: 10.1111/1541-4337.13426.

Unsalted tomato juice intake improves blood pressure and serum low-density lipoprotein cholesterol level in local Japanese residents at risk of cardiovascular disease.

Odai T, Terauchi M, Okamoto D, Hirose A, Miyasaka N Food Sci Nutr. 2019; 7(7):2271-2279.

PMID: 31367355 PMC: 6657743. DOI: 10.1002/fsn3.1066.

References

Deplanque D, Gele P, Petrault O, Six I, Furman C, Bouly M . Peroxisome proliferator-activated receptor-alpha activation as a mechanism of preventive neuroprotection induced by chronic fenofibrate treatment. J Neurosci. 2003; 23(15):6264-71. PMC: 6740545. View

Ibarra-Lara L, Cervantes-Perez L, Perez-Severiano F, Del Valle L, Rubio-Ruiz E, Soria-Castro E . PPARalpha stimulation exerts a blood pressure lowering effect through different mechanisms in a time-dependent manner. Eur J Pharmacol. 2009; 627(1-3):185-93. DOI: 10.1016/j.ejphar.2009.10.039. View

Kim J, Paik J, Kim O, Park H, Lee J, Jang Y . Effects of lycopene supplementation on oxidative stress and markers of endothelial function in healthy men. Atherosclerosis. 2011; 215(1):189-95. DOI: 10.1016/j.atherosclerosis.2010.11.036. View

Delerive P, Gervois P, Fruchart J, Staels B . Induction of IkappaBalpha expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-alpha activators. J Biol Chem. 2000; 275(47):36703-7. DOI: 10.1074/jbc.M004045200. View

Palozza P, Simone R, Catalano A, Monego G, Barini A, Mele M . Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-κB nuclear binding and increase in PPARγ expression. J Nutr Biochem. 2010; 22(3):259-68. DOI: 10.1016/j.jnutbio.2010.02.003. View

Klipstein-Grobusch K, Launer L, Geleijnse J, Boeing H, Hofman A, Witteman J . Serum carotenoids and atherosclerosis. The Rotterdam Study. Atherosclerosis. 1999; 148(1):49-56. DOI: 10.1016/s0021-9150(99)00221-x. View

Varga T, Czimmerer Z, Nagy L . PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation. Biochim Biophys Acta. 2011; 1812(8):1007-22. PMC: 3117990. DOI: 10.1016/j.bbadis.2011.02.014. View

Gajendragadkar P, Hubsch A, Maki-Petaja K, Serg M, Wilkinson I, Cheriyan J . Effects of oral lycopene supplementation on vascular function in patients with cardiovascular disease and healthy volunteers: a randomised controlled trial. PLoS One. 2014; 9(6):e99070. PMC: 4049604. DOI: 10.1371/journal.pone.0099070. View

Hirose A, Terauchi M, Tamura M, Akiyoshi M, Owa Y, Kato K . Tomato juice intake increases resting energy expenditure and improves hypertriglyceridemia in middle-aged women: an open-label, single-arm study. Nutr J. 2015; 14:34. PMC: 4406031. DOI: 10.1186/s12937-015-0021-4. View

10.

Ibarra-Lara L, Hong E, Soria-Castro E, Torres-Narvaez J, Perez-Severiano F, Del Valle-Mondragon L . Clofibrate PPARα activation reduces oxidative stress and improves ultrastructure and ventricular hemodynamics in no-flow myocardial ischemia. J Cardiovasc Pharmacol. 2012; 60(4):323-34. DOI: 10.1097/FJC.0b013e31826216ed. View

11.

Rissanen T, Voutilainen S, Nyyssonen K, Lakka T, Sivenius J, Salonen R . Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study. Br J Nutr. 2001; 85(6):749-54. DOI: 10.1079/bjn2001357. View

12.

Kim Y, Hirai S, Takahashi H, Goto T, Ohyane C, Tsugane T . 9-oxo-10(E),12(E)-Octadecadienoic acid derived from tomato is a potent PPAR α agonist to decrease triglyceride accumulation in mouse primary hepatocytes. Mol Nutr Food Res. 2011; 55(4):585-93. DOI: 10.1002/mnfr.201000264. View

13.

Libby P, Aikawa M, Schonbeck U . Cholesterol and atherosclerosis. Biochim Biophys Acta. 2000; 1529(1-3):299-309. DOI: 10.1016/s1388-1981(00)00161-x. View

14.

Palozza P, Parrone N, Simone R, Catalano A . Lycopene in atherosclerosis prevention: an integrated scheme of the potential mechanisms of action from cell culture studies. Arch Biochem Biophys. 2010; 504(1):26-33. DOI: 10.1016/j.abb.2010.06.031. View

15.

Palozza P, Simone R, Catalano A, Parrone N, Monego G, Ranelletti F . Lycopene regulation of cholesterol synthesis and efflux in human macrophages. J Nutr Biochem. 2011; 22(10):971-8. DOI: 10.1016/j.jnutbio.2010.08.010. View

16.

Kim Y, Hirai S, Goto T, Ohyane C, Takahashi H, Tsugane T . Potent PPARα activator derived from tomato juice, 13-oxo-9,11-octadecadienoic acid, decreases plasma and hepatic triglyceride in obese diabetic mice. PLoS One. 2012; 7(2):e31317. PMC: 3276502. DOI: 10.1371/journal.pone.0031317. View

17.

Fujiwara Y, Kiyota N, Hori M, Matsushita S, Iijima Y, Aoki K . Esculeogenin A, a new tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in ApoE-deficient mice by inhibiting ACAT. Arterioscler Thromb Vasc Biol. 2007; 27(11):2400-6. DOI: 10.1161/ATVBAHA.107.147405. View

18.

Hsu Y, Lai C, Chang C, Fan C, Chen C, Wu C . Characterizing the lipid-lowering effects and antioxidant mechanisms of tomato paste. Biosci Biotechnol Biochem. 2008; 72(3):677-85. DOI: 10.1271/bbb.70402. View

19.

Sander D, Kukla C, Klingelhofer J, Winbeck K, Conrad B . Relationship between circadian blood pressure patterns and progression of early carotid atherosclerosis: A 3-year follow-up study. Circulation. 2000; 102(13):1536-41. DOI: 10.1161/01.cir.102.13.1536. View

20.

Cao H, Wen G, Li H . Role of peroxisome proliferator-activated receptor α in atherosclerosis. Mol Med Rep. 2014; 9(5):1755-60. DOI: 10.3892/mmr.2014.2020. View