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Lung Cancer Mortality in the Lung Screening Study Feasibility Trial

Overview
Journal JNCI Cancer Spectr
Publisher Oxford University Press
Specialty Oncology
Date 2019 Jul 31
PMID 31360863
Citations 19
Authors
Maryam Doroudi
Paul F Pinsky
Pamela M Marcus
Affiliations
Soon will be listed here.
Abstract

The Lung Screening Study was a multicenter controlled feasibility trial that randomly assigned subjects to undergo two rounds of screening with either low-dose spiral computed tomography (LDCT) or chest X-ray (CXR). Long-term follow-up was performed to evaluate any differences in lung-cancer-specific and all-cause mortality between arms. In 2000, subjects were randomly assigned at six screening centers. Linkage with the National Death Index was performed to ascertain long-term mortality for subjects. Median follow-up for mortality of the 1660 and 1658 subjects randomly assigned to LDCT and CXR, respectively, was 5.2 years. There were 32 and 26 deaths from lung cancer in the two groups, respectively, corresponding to lung cancer death rates of 3.84 and 3.10 per 1000 person-years, and a risk ratio of 1.24 (95% confidence interval = 0.74 to 2.08). The risk ratio for all-cause mortality was 1.20 (95% confidence interval = 0.94 to 1.54). These findings can contribute to the overall knowledge on LDCT lung cancer screening.

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References
1.
Gohagan J, Marcus P, Fagerstrom R, Pinsky P, Kramer B, Prorok P . Baseline findings of a randomized feasibility trial of lung cancer screening with spiral CT scan vs chest radiograph: the Lung Screening Study of the National Cancer Institute. Chest. 2004; 126(1):114-21. DOI: 10.1378/chest.126.1.114. View
2.
Gohagan J, Marcus P, Fagerstrom R, Pinsky P, Kramer B, Prorok P . Final results of the Lung Screening Study, a randomized feasibility study of spiral CT versus chest X-ray screening for lung cancer. Lung Cancer. 2004; 47(1):9-15. DOI: 10.1016/j.lungcan.2004.06.007. View
3.
Xu D, Gietema H, de Koning H, Vernhout R, Nackaerts K, Prokop M . Nodule management protocol of the NELSON randomised lung cancer screening trial. Lung Cancer. 2006; 54(2):177-84. DOI: 10.1016/j.lungcan.2006.08.006. View
4.
Aberle D, Adams A, Berg C, Black W, Clapp J, Fagerstrom R . Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 2011; 365(5):395-409. PMC: 4356534. DOI: 10.1056/NEJMoa1102873. View
5.
Pastorino U, Rossi M, Rosato V, Marchiano A, Sverzellati N, Morosi C . Annual or biennial CT screening versus observation in heavy smokers: 5-year results of the MILD trial. Eur J Cancer Prev. 2012; 21(3):308-15. DOI: 10.1097/CEJ.0b013e328351e1b6. View