Non-small-cell Lung Cancer

Overview

Journal Nat Rev Dis Primers

Specialty General Medicine

Date 2024 Sep 26

PMID 39327441

Authors

Lizza E L Hendriks

Jordi Remon

Corinne Faivre-Finn

Marina C Garassino

John V Heymach

Keith M Kerr

Daniel S W Tan

Giulia Veronesi

Martin Reck

Affiliations

Soon will be listed here.

Abstract

Non-small-cell lung cancer (NSCLC) is one of the most frequent cancer types and is responsible for the majority of cancer-related deaths worldwide. The management of NSCLC has improved considerably, especially in the past 10 years. The systematic screening of populations at risk with low-dose CT, the implementation of novel surgical and radiotherapeutic techniques and a deeper biological understanding of NSCLC that has led to innovative systemic treatment options have improved the prognosis of patients with NSCLC. In non-metastatic NSCLC, the combination of various perioperative strategies and adjuvant immunotherapy in locally advanced disease seem to enhance cure rates. In metastatic NSCLC, the implementation of novel drugs might prolong disease control together with preserving quality of life. The further development of predictive clinical and genetic markers will be essential for the next steps in individualized treatment concepts.

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