Gene Expressions of De Novo Hepatic Lipogenesis in Feline Hepatic Lipidosis

Overview

Journal J Feline Med Surg

Specialty Veterinary Medicine

Date 2019 Jul 20

PMID 31322470

Citations 3

Authors

Chiara Valtolina

Joris H Robben

Monique E van Wolferen

Hedwig S Kruitwagen

Ronald J Corbee

Robert P Favier

Louis C Penning

Affiliations

Soon will be listed here.

Abstract

Objectives: The aim of this study was to evaluate if de novo hepatic lipid synthesis contributes to fatty acid overload in the liver of cats with feline hepatic lipidosis (FHL).

Methods: Lipogenic gene expression of peroxisome proliferator-activated receptor-alpha (), peroxisome proliferator-activated receptor-gamma (), fatty acid synthase () and sterol regulatory element-binding factor () were evaluated using quantitative RT-PCR in liver tissue of six cats with FHL and compared with the liver tissue of eight healthy cats.

Results: In liver tissue, and mRNA expression levels were not significantly different ( >0.12, >0.89 and >0.5, respectively) in the FHL group compared with the control group. gene expression was downregulated around 10-fold in the FHL group vs the control group ( = 0.039).

Conclusions And Relevance: The downregulation of in the liver tissue of cats with FHL does not support the hypothesis that de novo lipogenesis in the liver is an important pathway of fatty acid accumulation in FHL.

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