Rapid Development of Fasting-induced Hepatic Lipidosis in the American Mink (Neovison Vison): Effects of Food Deprivation and Re-alimentation on Body Fat Depots, Tissue Fatty Acid Profiles, Hematology and Endocrinology

Overview

Journal Lipids

Specialty Biochemistry

Date 2009 Dec 19

PMID 20020218

Citations 13

Authors

Kirsti Rouvinen-Watt

Anne-Mari Mustonen

Rebecca Conway

Catherine Pal

Lora Harris

Seppo Saarela

Ursula Strandberg

Petteri Nieminen

Affiliations

Soon will be listed here.

Abstract

Hepatic lipidosis is a common pathological finding in the American mink (Neovison vison) and can be caused by nutritional imbalance due to obesity or rapid body weight loss. The objectives of the present study were to investigate the timeline and characterize the development of hepatic lipidosis in mink in response to 0-7 days of food deprivation and liver recovery after 28 days of re-feeding. We report here the effects on hematological and endocrine variables, body fat mobilization, the development of hepatic lipidosis and the alterations in the liver lipid classes and tissue fatty acid (FA) sums. Food deprivation resulted in the rapid mobilization of body fat, most notably visceral, causing elevated hepatosomatic index and increased liver triacylglycerol content. The increased absolute amounts of liver total phospholipids and phosphatidylcholine suggested endoplasmic reticulum stress. The hepatic lipid infiltration and the altered liver lipid profiles were associated with a significantly reduced proportion of n-3 polyunsaturated FA (PUFA) in the livers and the decrease was more evident in the females. Likewise, re-feeding of the female mink resulted in a more pronounced recovery of the liver n-3 PUFA. The rapid decrease in the n-3/n-6 PUFA ratio in response to food deprivation could trigger an inflammatory response in the liver. This could be a key contributor to the pathophysiology of fatty liver disease in mink influencing disease progression.

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