Doebner-type Pyrazolopyridine Carboxylic Acids in an Ugi Four-component Reaction

Overview

Journal Beilstein J Org Chem

Specialty Chemistry

Date 2019 Jul 12

PMID 31293676

Citations 3

Authors

Maryna V Murlykina

Oleksandr V Kolomiets

Maryna M Kornet

Yana I Sakhno

Sergey M Desenko

Victoriya V Dyakonenko

Svetlana V Shishkina

Oleksandr A Brazhko

Vladimir I Musatov

Alexander V Tsygankov

Erik V Van der Eycken

Valentyn A Chebanov

Affiliations

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Abstract

Substituted 1-pyrazolo[3,4-]pyridine-4- and 1-pyrazolo[3,4-]pyridine-6-carboxamides have been synthetized through a Doebner-Ugi multicomponent reaction sequence in a convergent and versatile manner using diversity generation strategies: combination of two multicomponent reactions and conditions-based divergence strategy. The target products contain as pharmacophores pyrazolopyridine and peptidomimetic moieties with four points of diversity introduced from readily available starting materials including scaffold diversity. A small focused compound library of 23 Ugi products was created and screened for antibacterial activity.

Citing Articles

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Synthesis of imidazo[1,2-]pyridine-containing peptidomimetics by tandem of Groebke-Blackburn-Bienaymé and Ugi reactions.

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