Enols As Feasible Acid Components in the Ugi Condensation

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2012 Dec 4

PMID 23199185

Citations 6

Authors

Teresa G Castellano

Ana G Neo

Stefano Marcaccini

Carlos F Marcos

Affiliations

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Abstract

Heterocyclic enols are used for the first time as acid components in an Ugi-type multicomponent condensation. For that purpose, we have chosen enols containing a Michael acceptor, in order to facilitate an irreversible rearrangement of the primary Ugi adduct. The new four-component process leads readily and efficiently to heterocyclic enamines containing at least six elements of diversity.

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